SubsidieMeestersMonitoring of stroke patients with 3D ultrasound localization microscopy
The ERC POC StrokeMonitor project aims to validate a portable super-resolution ultrasound device for monitoring delayed cerebral ischemia in stroke patients, enhancing neuroimaging accessibility and accuracy.
Projectdetails
Introduction
The ERC Cog ResolveStroke has led to the development of a new imaging device, based on super-resolution ultrasound, which can assess ischemic and hemorrhagic stroke through the observation of the smallest blood vessels that are invisible to other medical imaging modalities.
Current Status
This StrokeScanner is currently being demonstrated in large models before being applied to human studies at the end of the project. Its remarkable results have led to the creation of a startup (Resolve Stroke) which conceives a portable and 3D super-resolution ultrasound scanner to improve access to neuroimaging for stroke patients.
Clinical Need
In particular, there is a dire need to monitor the cerebral blood flows at the patient’s bedside after the acute phase. Delayed cerebral ischemia arises in a third of all patients suffering from subarachnoid hemorrhage (about 800,000 cases worldwide per year).
- Transcranial Doppler is used to explore large vessel circulation but is blind to fine vascular alterations.
Potential Impact
We believe that ultrasound super-resolution could bring a new diagnostic tool to help patients and physicians, with a resolution and sensitivity comparable to CT Angiography on a device smaller than carry-on luggage.
Project Goals
The goal of the ERC POC StrokeMonitor is to establish the performance and usefulness of this approach to monitor Delayed Cerebral Ischemia. The demonstration will be performed both in models and in human patients.
- A model of subarachnoid hemorrhage will be imaged over several days to determine the dynamics of the microcirculation alterations.
- A clinically validated StrokeScanner will then be tested on SAH patients at CHU de Caen to identify biomarkers of delayed cerebral ischemia in hemorrhagic stroke patients.
Future Directions
Through this ERC POC StrokeMonitor, we will extend the applicability of the StrokeScanner in neurovascular units in hospitals to help patients’ follow-up and generate stronger proof of ultrasound super-resolution for neuroimaging.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-2-2023 |
| Einddatum | 31-7-2024 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRSpenvoerder
- RESOLVE STROKE SAS
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Single-fibre based holographic endoscope for observations of stroke in deep brain structureStrokeGATE aims to enhance a multimode fibre-based holographic endoscope for investigating deep-brain stroke effects in living models, advancing neuroscience research and commercialization. | ERC Proof of... | € 150.000 | 2022 | Details |
Super-resolution, ultrafast and deeply-learned contrast ultrasound imaging of the vascular tree.Super-FALCON aims to revolutionize cardiovascular and cancer imaging by using advanced plane-wave ultrasound with microbubbles for precise, high-resolution flow imaging, enhancing diagnosis and treatment. | ERC Starting... | € 1.500.000 | 2023 | Details |
Whole-organ 3D ultrasound micro-flow imaging: from basics physics to clinical proof-of-concept on cardiac and cerebral diseasesMicroflowLife aims to develop ultrasensitive 3D ultrasound localization microscopy for mapping microcirculation in the heart and brain, enhancing early disease diagnosis and monitoring. | ERC Starting... | € 1.500.000 | 2022 | Details |
Signal-enhanced MRI contrast agents for neurodegenerationThis project aims to develop and validate new magnetic resonance technologies for early, non-invasive diagnosis of neurodegenerative diseases using metabolic contrast agents. | ERC Proof of... | € 150.000 | 2022 | Details |
Accurate quantification of neurologic disease over timeThe project aims to develop CHRONOS, an AI-driven diagnostic tool using synthetic biomaps to enable earlier and more accurate detection of brain tumors, facilitating timely clinical decisions. | ERC Proof of... | € 150.000 | 2025 | Details |
Single-fibre based holographic endoscope for observations of stroke in deep brain structure
StrokeGATE aims to enhance a multimode fibre-based holographic endoscope for investigating deep-brain stroke effects in living models, advancing neuroscience research and commercialization.
Super-resolution, ultrafast and deeply-learned contrast ultrasound imaging of the vascular tree.
Super-FALCON aims to revolutionize cardiovascular and cancer imaging by using advanced plane-wave ultrasound with microbubbles for precise, high-resolution flow imaging, enhancing diagnosis and treatment.
Whole-organ 3D ultrasound micro-flow imaging: from basics physics to clinical proof-of-concept on cardiac and cerebral diseases
MicroflowLife aims to develop ultrasensitive 3D ultrasound localization microscopy for mapping microcirculation in the heart and brain, enhancing early disease diagnosis and monitoring.
Signal-enhanced MRI contrast agents for neurodegeneration
This project aims to develop and validate new magnetic resonance technologies for early, non-invasive diagnosis of neurodegenerative diseases using metabolic contrast agents.
Accurate quantification of neurologic disease over time
The project aims to develop CHRONOS, an AI-driven diagnostic tool using synthetic biomaps to enable earlier and more accurate detection of brain tumors, facilitating timely clinical decisions.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Advancing stroke care with cutting-edge ultrasound biomarkers for Neurocritical CareResolve Stroke aims to enhance ultrasound imaging with the SYLVER system to improve stroke diagnosis and management through innovative biomarkers, making timely detection more accessible and effective. | EIC Transition | € 2.493.436 | 2025 | Details |
Project MITH Nico.labDit project onderzoekt de haalbaarheid van EEG-herseninfarct triage in ambulances met AI-algoritmen om snel en nauwkeurig patiënten te identificeren voor directe behandeling. | Mkb-innovati... | € 20.000 | 2020 | Details |
Remote whole-brain functional microscopy of the vascular system: a paradigm shift for the monitoring and treatment of small vessel diseasesThe project aims to revolutionize neuroimaging by developing functional Ultrasound Localization Microscopy (fULM) for high-resolution monitoring of brain vasculature and function, enhancing disease diagnosis and treatment evaluation. | EIC Pathfinder | € 3.946.172 | 2022 | Details |
StrokePointerTrianecT ontwikkelt StrokePointer, een medisch EEG-apparaat voor ambulancepersoneel om binnen 3 minuten LVO-herseninfarcten te detecteren, met als doel snellere en betere patiëntverzorging. | Mkb-innovati... | € 20.000 | 2023 | Details |
Paradigm shift in stroke: accurate diagnosis and evaluation of all treatment options in any hospital, at any timeMethinks aims to transform stroke diagnosis by enabling all hospitals to evaluate treatment options using standard imaging, reducing time-to-treatment and improving patient outcomes globally. | EIC Accelerator | € 2.495.415 | 2023 | Details |
Advancing stroke care with cutting-edge ultrasound biomarkers for Neurocritical Care
Resolve Stroke aims to enhance ultrasound imaging with the SYLVER system to improve stroke diagnosis and management through innovative biomarkers, making timely detection more accessible and effective.
Project MITH Nico.lab
Dit project onderzoekt de haalbaarheid van EEG-herseninfarct triage in ambulances met AI-algoritmen om snel en nauwkeurig patiënten te identificeren voor directe behandeling.
Remote whole-brain functional microscopy of the vascular system: a paradigm shift for the monitoring and treatment of small vessel diseases
The project aims to revolutionize neuroimaging by developing functional Ultrasound Localization Microscopy (fULM) for high-resolution monitoring of brain vasculature and function, enhancing disease diagnosis and treatment evaluation.
StrokePointer
TrianecT ontwikkelt StrokePointer, een medisch EEG-apparaat voor ambulancepersoneel om binnen 3 minuten LVO-herseninfarcten te detecteren, met als doel snellere en betere patiëntverzorging.
Paradigm shift in stroke: accurate diagnosis and evaluation of all treatment options in any hospital, at any time
Methinks aims to transform stroke diagnosis by enabling all hospitals to evaluate treatment options using standard imaging, reducing time-to-treatment and improving patient outcomes globally.