CHerenkov Light mOdulE for time-of-flight Positron Emission Tomography

The CHLOE-PET project aims to develop an advanced gamma detector for TOF-PET that enhances time and spatial resolution by up to 7 and 10 times, improving cancer diagnostics without extra costs.

Subsidie
€ 1.384.755
2023

Projectdetails

Introduction

Time-of-flight positron emission tomography (TOF-PET) is the standard-of-care in cancer detection. TOF-PET scanners’ performance is dependent on the radiation detectors they use. Improving time and spatial detection features in such detectors will dramatically impact the diagnostic capacity of TOF-PET systems.

Project Goal

The goal of this project is to build a gamma detector concept for TOF-PET able to improve the time resolution and spatial segmentation of state-of-the-art detectors by a factor of up to 7 and 10, respectively, without additional production costs.

CHLOE-PET Design

CHLOE-PET is a forward-looking gamma detector design for TOF-PET able to exploit the new photodetector technologies that are currently under development and will become available within the next 5-to-10 years.

Novelty of the Design

The novelty of the proposed design lies in the following aspects:

  1. Using Cherenkov light as a prompt time source.
  2. Utilizing an innovative geometry optimized to maximize light collection.
  3. Employing photodetectors with small pixel pitch.

This project is the first attempt to build a detector module scalable to a full-size system that can be used in a hospital setting.

Technical Specifications

The CHLOE-PET detector will consist of bismuth germanate (BGO) crystals with 12 mm thickness and will combine the readout of scintillation and Cherenkov light.

Performance Metrics

CHLOE-PET will provide:

  • An effective 3D segmentation of 2x2x2 mm³.
  • An intrinsic photon time spread of 20 ps.
  • No intrinsic radiation background (unlike state-of-the-art TOF-PET detectors).

Impact of Improvements

Such improvements will allow for:

  • Increasing the signal-to-noise ratio of images by >2-fold.
  • Detecting lesions of 2 mm size (>3 times the current performance).
  • Building portable high-performance organ-dedicated TOF-PET systems.
  • Universalizing the use of dynamic TOF-PET studies.

The combination of these outcomes will provide significantly better diagnostic capabilities in a range of fields such as oncology, neurology, or cardiology, among others, and ultimately boost treatment efficacy and patient comfort.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 1.384.755
Totale projectbegroting€ 1.384.755

Tijdlijn

Startdatum1-9-2023
Einddatum31-8-2027
Subsidiejaar2023

Partners & Locaties

Projectpartners

  • INSTITUTO DE FISICA DE ALTAS ENERGIASpenvoerder

Land(en)

Spain

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