Enabling advances in diagnosis, patient stratification and treatment for dilated cardiomyopathy patients and families.
The DCM-NEXT consortium aims to enhance genetic testing and develop novel therapies for dilated cardiomyopathy by leveraging extensive clinical and omics data from 11,750 patients.
Projectdetails
Introduction
Dilated Cardiomyopathy (DCM) is a heart muscle disorder characterised by thinning and stretching of the heart ventricles, making it harder for the heart to pump blood (systolic dysfunction). This disorder, with an estimated prevalence of up to 1/250, predominantly affects younger adults. It is associated with significant morbidity and mortality, including heart failure and sudden cardiac death, with end-stage DCM being the leading indication for heart transplantation.
Disease Burden
The current disease burden in DCM is largely attributable to two important gaps in scientific knowledge:
- Our understanding of the aetiology and genetic architecture of DCM remains limited, hindering the utility of genetic testing in clinical patient management.
- There are limited therapeutic options for DCM patients. Existing therapies are generic and target symptoms. No curative treatments exist, apart from invasive heart transplantation, and there are no approved therapies targeting underlying molecular disease mechanisms.
A fuller understanding of the genetic architecture of DCM and knowledge of the genes and genetic variants involved are critically needed to provide solutions for these unmet medical needs.
DCM-NEXT Consortium
The DCM-NEXT consortium combines world-leading interdisciplinary expertise and resources of 8 investigators in the fields of DCM, deep clinical phenotyping, cardiogenomics, cardiac transcriptomics, artificial intelligence, in silico drug target discovery, and functional studies. They will uniquely leverage their unparalleled cohort of 11,750 DCM probands and relatives with extensive clinical and omics data.
Project Aims
Through cutting-edge genomic and cardiac transcriptomic studies, the project aims to:
- Revolutionise genetic testing and patient stratification for more precise prediction of disease onset, progression, and risk of major adverse cardiac events.
- Accelerate the development of novel therapies by identifying and validating targets involved in the pathogenesis of DCM.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 4.137.668 |
Totale projectbegroting | € 4.137.718 |
Tijdlijn
Startdatum | 1-10-2023 |
Einddatum | 30-9-2027 |
Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- STICHTING AMSTERDAM UMCpenvoerder
- MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
- CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
- SERVICIO MADRILENO DE SALUD
- UNIVERSITEIT MAASTRICHT
- FONDATION CARDIOMETABOLISME NUTRITION
- FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO PUERTA DE HIERRO-MAJADAHONDA
- IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Land(en)
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Comprehensive Analysis of RBM20-induced Dilated Cardiomyopathies using Omics Approaches and Repair Interventions
CARDIOREPAIR aims to identify and therapeutically target RBM20 mutations in dilated cardiomyopathy using high-throughput genomics and bioengineering to improve heart health outcomes.
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The project aims to integrate genomics, proteomics, and structural analyses to clarify genotype-phenotype relationships in arrhythmogenic cardiomyopathy, paving the way for novel therapies.
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The B-specific consortium aims to identify and target specific B-cell subsets to develop personalized therapies for atherosclerosis and improve cardiovascular disease risk assessment and management.
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Universal Cardiac Mesoangioblasts for treating DMD Dilated CardiomyopathyThe project aims to develop immune-privileged cardiac mesoangioblasts that can be converted to cardioblasts for targeted treatment of dilated cardiomyopathy, enhancing heart repair. | ERC Proof of... | € 150.000 | 2025 | Details |
Development of novel 3D vascularized cardiac models to investigate Coronary Microvascular DiseaseThe 3DVasCMD project aims to develop a 3D vascularized cardiac model using iPSC technology to study coronary microvascular disease and identify therapeutic targets for improved cardiovascular health. | ERC Starting... | € 1.496.395 | 2022 | Details |
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Advanced human models of the heart to understand cardiovascular diseaseHeart2Beat aims to develop innovative 3D human cardiac models using microfluidic technology to enhance understanding and treatment of cardiovascular diseases through personalized medicine. | ERC Advanced... | € 2.500.000 | 2023 | Details |
Universal Cardiac Mesoangioblasts for treating DMD Dilated Cardiomyopathy
The project aims to develop immune-privileged cardiac mesoangioblasts that can be converted to cardioblasts for targeted treatment of dilated cardiomyopathy, enhancing heart repair.
Development of novel 3D vascularized cardiac models to investigate Coronary Microvascular Disease
The 3DVasCMD project aims to develop a 3D vascularized cardiac model using iPSC technology to study coronary microvascular disease and identify therapeutic targets for improved cardiovascular health.
Dynamic engIneered heart tiSsue to Study intEr-individual susCeptibily and improve Treatment of Heart Failure
DISSECT-HF aims to engineer heart tissue from patient-specific stem cells to uncover common mechanisms of heart failure across different etiologies and improve treatment strategies.
The transcriptional regulation of cardiomyocyte polyploidization and its relevance in cardiac regeneration
REACTIVA aims to promote heart regeneration by reactivating adult diploid cardiomyocytes through a newly identified regulatory network and inhibiting a specific transcription factor.
Advanced human models of the heart to understand cardiovascular disease
Heart2Beat aims to develop innovative 3D human cardiac models using microfluidic technology to enhance understanding and treatment of cardiovascular diseases through personalized medicine.