SubsidieMeestersDevelopment of nutritional vesicles for precision diagnostics and therapeutics for metabolic diseases
The NutriEV project investigates food-derived extracellular vesicles as superfoods and biosensors to enhance gut health and metabolic regulation through innovative research and non-invasive biomonitoring.
Projectdetails
Introduction
The NutriEV project explores the pivotal role of extracellular vesicles (EVs) derived from food in nutrition. These nutriEVs are envisioned to serve as superfoods and nutritional biosensors. The project integrates various disciplines, including nutrition, microbiome research, glycan analysis, molecular biology, nanoreagent assembly, biosensors, organoid technologies, in vivo models, and clinical research.
Research Focus
NutriEVs obtained from raw and fermented foods are a model for our research. Investigating the glycans associated with NutriEVs will provide insights into how these vesicles may deliver their nutritional cargo to cells.
Digestive Process and Impact
NutriEVs can withstand the digestive process, influencing the gut microbiome and other gut-resident cells, including their secreted EVs. Subsequently, they transcytose across the gut wall into the bloodstream, impacting cellular metabolism and disease.
Interdisciplinary Approach
The project delves into the intricate interplay between dietary EVs, gut residence cells, the microbiome, and their associated EVs. We aim to understand their role in gut health, obesity, and metabolic regulation through a comprehensive array of in vitro, in vivo, and clinical investigations.
Non-Invasive Biomonitoring
These EVs are detected in sweat with unique molecular signatures, providing non-invasive biomonitoring technologies to assess nutritional impact. These technologies can potentially revolutionize our ability to evaluate the influence of nutrition.
Conclusion
The successful completion of the NutriEV project presents promising translational opportunities for both the food industry and medicine.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 3.943.243 |
| Totale projectbegroting | € 3.943.243 |
Tijdlijn
| Startdatum | 1-9-2024 |
| Einddatum | 31-8-2028 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- OULUN YLIOPISTOpenvoerder
- CONSIGLIO NAZIONALE DELLE RICERCHE
- TECHNISCHE UNIVERSITAET BRAUNSCHWEIG
- KOBENHAVNS UNIVERSITET
- ZABALA INNOVATION CONSULTING SA
Land(en)
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