SubsidieMeestersINTELLIGENT ENCAPSULATION AND SCREENING PLATFORM FOR PRECISION DELIVERY OF PROBIOTICS TO IMPROVE GUT HEALTH
iNSIGHT aims to develop precision probiotics through innovative microencapsulation for targeted delivery, enhancing gut health and addressing related diseases using advanced technology and personalized treatment.
Projectdetails
Introduction
Over the past century, drastic lifestyle changes have caused disbalanced gut microbiota, which has been linked to various health conditions and noncommunicable diseases. Probiotics are a promising route for restoring a healthy gut microbiome, but their inherent sensitivity towards oxygen, water, heat, and/or gastric acid greatly hampers their widespread application in disease prevention and treatment programs.
Project Objective
iNSIGHT solves this longstanding challenge by realizing precision probiotics via a novel and disruptive microencapsulation approach. We set ourselves the goal to investigate and develop a tunable microcapsule formulation and scalable encapsulation process for the protection and targeted post-stomach delivery of sensitive probiotic formulations.
Methodology
Specifically, we will work on unique bi-gel-based microencapsulation formulations that are expected to provide unsurpassed protection to probiotics. To study the structural breakdown of capsules and thereby the controlled release of probiotics, we will develop and test a novel gut-on-a-chip microfluidic device.
Incorporation of Technology
To obtain more in-depth knowledge as well as prepare for high-throughput screenings, we incorporate machine learning for:
- Automated investigation of digestion kinetics under personalizable conditions.
- Automated in-line identification, evaluation, and adjustment of microcapsule synthesis.
Proof of Concept
As a proof of concept, we will leverage our encapsulation and screening platforms to protect a sensitive next-generation strain and make our precision probiotics formulation available to patients via personalized treatment of a patient cohort under pharmacy legislation.
Conclusion
iNSIGHT forms the basis for protection and delivery of sensitive probiotic ingredients, and thereby contributes to the prevention, alleviation, and/or treatment of myriad health conditions related to unhealthy gut microbiota.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 3.194.343 |
| Totale projectbegroting | € 3.691.038 |
Tijdlijn
| Startdatum | 1-2-2025 |
| Einddatum | 31-1-2029 |
| Subsidiejaar | 2025 |
Partners & Locaties
Projectpartners
- WAGENINGEN UNIVERSITYpenvoerder
- IamFluidics B.V.
- KITOZYME SA
- FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
- ALTECHNA R&D UAB
- MICROBIOME CENTER B.V.
Land(en)
Vergelijkbare projecten binnen EIC Pathfinder
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|---|---|---|---|---|
ISOS-Implantable Ecosystems of Genetically Modified Bacteria for the Personalized Treatment of Patients with Chronic DiseasesISOS aims to create a personalized bioreactor using engineered probiotics for on-demand delivery of therapeutic compounds to treat chronic diseases like age-related macular degeneration. | EIC Pathfinder | € 2.433.300 | 2023 | Details |
Bugs4Urate - Precision Nutrition Strategies for Investigating Probiotic, Diet, Glycan, and Microbiome Factors in Hyperuricemia and Gout PreventionThis project aims to develop a precision nutrition approach using a novel probiotic to lower urate levels and prevent gout by analyzing gut microbiome interactions and individual responses. | EIC Pathfinder | € 3.765.840 | 2024 | Details |
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ISOS-Implantable Ecosystems of Genetically Modified Bacteria for the Personalized Treatment of Patients with Chronic Diseases
ISOS aims to create a personalized bioreactor using engineered probiotics for on-demand delivery of therapeutic compounds to treat chronic diseases like age-related macular degeneration.
Bugs4Urate - Precision Nutrition Strategies for Investigating Probiotic, Diet, Glycan, and Microbiome Factors in Hyperuricemia and Gout Prevention
This project aims to develop a precision nutrition approach using a novel probiotic to lower urate levels and prevent gout by analyzing gut microbiome interactions and individual responses.
Enteric Bioelectronics for Sensing and Stimulating the CNS
EnterBio aims to develop bioelectronic tools for non-invasive modulation of the enteric nervous system to improve treatment of neurological disorders by leveraging gut-brain interactions.
Understanding the potential of modulating Host-Microbiome-Glycan interactions (“the triangle of sweetness”) to tackle non-communicable diseases
The project aims to identify novel glycosyltransferases and HMOs, analyze their gut interactions, and validate an HMO for inflammation relief, enhancing glycobiology research and therapeutic applications.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
PRoduction of an innOvative Millifluidic dEvice for TEsting of new prObioticsThe PROMETEO project aims to develop a millifluidic platform for studying probiotics in the gut microenvironment, enhancing drug development and clinical trial success rates. | ERC Proof of... | € 150.000 | 2023 | Details |
Microbial Synthetic in vivo Cell Therapy SystemsThe MiStiC project aims to develop Clostridium leptum as a stable chassis for localized drug production and delivery, targeting colorectal cancer through engineered biosensors and natural product pathways. | ERC Starting... | € 1.499.938 | 2023 | Details |
SYNergize: Understanding spore-forming gut bacteria biology to target pathogensSYNergize aims to characterize gut spore-formers to develop synbiotics that inhibit pathogens and combat antimicrobial resistance through enhanced understanding of sporulation and transmission processes. | ERC Starting... | € 1.499.503 | 2024 | Details |
Advanced ingestibles for probing the nexus between gastrointestinal functions and physical/mental well-being in animals and humansThe DeepDive project aims to develop innovative ingestible devices for accurately mapping gastrointestinal signals to enhance understanding of their impact on physical and mental health in humans and animals. | ERC Proof of... | € 150.000 | 2024 | Details |
DE IN-AIR MICROFLUIDICS PILOT PLANT VOOR DUURZAME PRODUCTIE VAN MICROCAPSULES (TRL6 NAAR TRL8)IamFluidics en LT Technology ontwikkelen een duurzame micro-encapsulatie pilot plant voor natuurlijke oliën, gericht op het verminderen van microplastics en het verbeteren van productkwaliteit in cosmetica. | Mkb-innovati... | € 347.150 | 2021 | Details |
PRoduction of an innOvative Millifluidic dEvice for TEsting of new prObiotics
The PROMETEO project aims to develop a millifluidic platform for studying probiotics in the gut microenvironment, enhancing drug development and clinical trial success rates.
Microbial Synthetic in vivo Cell Therapy Systems
The MiStiC project aims to develop Clostridium leptum as a stable chassis for localized drug production and delivery, targeting colorectal cancer through engineered biosensors and natural product pathways.
SYNergize: Understanding spore-forming gut bacteria biology to target pathogens
SYNergize aims to characterize gut spore-formers to develop synbiotics that inhibit pathogens and combat antimicrobial resistance through enhanced understanding of sporulation and transmission processes.
Advanced ingestibles for probing the nexus between gastrointestinal functions and physical/mental well-being in animals and humans
The DeepDive project aims to develop innovative ingestible devices for accurately mapping gastrointestinal signals to enhance understanding of their impact on physical and mental health in humans and animals.
DE IN-AIR MICROFLUIDICS PILOT PLANT VOOR DUURZAME PRODUCTIE VAN MICROCAPSULES (TRL6 NAAR TRL8)
IamFluidics en LT Technology ontwikkelen een duurzame micro-encapsulatie pilot plant voor natuurlijke oliën, gericht op het verminderen van microplastics en het verbeteren van productkwaliteit in cosmetica.