Linking Intestinal Bacteria and Host Metabolism to Tackle Type 2 Diabetes with Novel Food
DiBaN aims to develop advanced platforms for testing novel insect-based foods to prevent intestinal dysbiosis and Type 2 diabetes, integrating AI for personalized nutritional interventions.
Projectdetails
Introduction
Poor nutritional regimes are main drivers of metabolic diseases and intestinal dysbiosis. Type 2 diabetes (T2D) prevalence is expected to reach 7% of the global population by 2023, and to curb its rise is an urgent public health need.
Importance of Intestinal Dysbiosis
Intestinal dysbiosis is a determinant factor in the progression of insulin resistance to T2D, shifting host metabolism through undefined mechanisms. Understanding these mechanisms is crucial to allow personalized interventions.
Challenges in Research
Advances have been limited by microbiome complexity and inter-individual variance. DiBaN binds together the necessary combination of expertise to address this question, based on the concept that the initial driver of the nutritional effects is the metabolic shift that takes place in the intestinal bacteria, which is transduced to the host.
Technological Needs
In this context, technological breakthrough tools for novel food development are an urgent need to prevent dysbiosis and T2D. DiBaN will overcome current limitations in nutrient-testing by developing advanced ex-vivo platforms that fully recapitulate the in vivo setting of dysbiosis and insulin resistance. These platforms will be validated with in vivo omic data.
Novel Food Development
To warrant the health-promoting effects of novel foods, we will test a new concept in the emerging field of insect food technology. This concept posits that adequate insect metabolic-intestinal health ensures the healthy properties of its derived products.
Validation and Biomarkers
The validation of this idea will also serve to identify biomarkers for the monitoring of the insects' health status. A. domesticus will be the testing model of choice due to its excellent nutritional profile, which will be boosted by complementing the insect's diet with microalgae bioactive-rich extracts.
Integration of Data
All these data will be integrated for the design of a pilot artificial intelligence (AI)-based application for the prediction of personalized responses to nutritional interventions.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 3.999.222 |
Totale projectbegroting | € 3.999.222 |
Tijdlijn
Startdatum | 1-10-2024 |
Einddatum | 30-9-2028 |
Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICASpenvoerder
- NUTRINSECT SRL
- UNIVERSIDAD AUTONOMA DE MADRID
- EPIDISEASE SL
- CENTRO DE CIENCIAS DO MAR DO ALGARVE
- FUNDACION IMDEA ALIMENTACION
Land(en)
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Glucose variability patterns for precision nutrition in diabetesThe GLUCOTYPES project aims to identify early glycaemic patterns and their dietary influences using advanced technologies to develop precision nutrition strategies for Type 2 diabetes prevention and management. | EIC Pathfinder | € 3.988.206 | 2024 | Details |
Precision nutrition approach for increasing fibre intake and health using microbiota-matched sustainable fibre sources
FIBRE-MATCH aims to personalize dietary fiber types to gut microbiome subtypes for improved metabolic outcomes and gastrointestinal health in individuals, particularly those with IBS.
Glucose variability patterns for precision nutrition in diabetes
The GLUCOTYPES project aims to identify early glycaemic patterns and their dietary influences using advanced technologies to develop precision nutrition strategies for Type 2 diabetes prevention and management.
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Resolving metabolic interactions between the gut microbiota and the host with multi-omics-based modellingThis project aims to systematically characterize gut bacteria interactions and their metabolic contributions to host health using experimental and computational methods, enabling targeted microbiota interventions. | ERC Starting... | € 1.499.323 | 2024 | Details |
Impact Of The Gut Microbiota On Host Cells Energy Metabolism: Role In Health And In Inflammatory bowel diseaseThe ENERGISED project aims to explore how altered gut microbiota affects host cell energy metabolism in inflammatory bowel diseases to develop new microbiota-based therapies. | ERC Consolid... | € 1.999.265 | 2022 | Details |
Nanostructure formation during food protein digestion and influence on intestinal transportPRODIGEST aims to enhance sustainable food production by investigating the structural and mechanistic aspects of protein digestion to improve nutrient bioavailability and health outcomes. | ERC Consolid... | € 2.355.741 | 2023 | Details |
Exploring functional inter-individual variations in the intestinal microbiome for personalized nutrition
The InterBiome project aims to explore how dietary components affect individual microbiota variations, influencing health outcomes and paving the way for personalized medicine and dietary strategies.
Dissection of the host-microbe crosstalk that controls metabolism and physiology in intestinal symbiosis
This project aims to explore the regulatory mechanisms of intestinal bacteria and their symbiotic relationship with hosts using Drosophila to enhance understanding of gut metabolism and health.
Resolving metabolic interactions between the gut microbiota and the host with multi-omics-based modelling
This project aims to systematically characterize gut bacteria interactions and their metabolic contributions to host health using experimental and computational methods, enabling targeted microbiota interventions.
Impact Of The Gut Microbiota On Host Cells Energy Metabolism: Role In Health And In Inflammatory bowel disease
The ENERGISED project aims to explore how altered gut microbiota affects host cell energy metabolism in inflammatory bowel diseases to develop new microbiota-based therapies.
Nanostructure formation during food protein digestion and influence on intestinal transport
PRODIGEST aims to enhance sustainable food production by investigating the structural and mechanistic aspects of protein digestion to improve nutrient bioavailability and health outcomes.