SubsidieMeestersBreaking the penetration limit of microscopy – Photoswitching Optoacoustics
SWOPT aims to revolutionize in vivo imaging by combining optoacoustic imaging and photoswitching to visualize individual cells deep within tissues, enhancing research in life sciences and biomedicine.
Projectdetails
Introduction
SWOPT is a novel imaging technology that will break through the penetration limits of optical microscopy to visualize individual cells and their function in vivo through several millimeters to centimeters of depth.
Technology Overview
SWOPT will exploit:
- Optoacoustic Imaging (OAI): A modality which combines signal generation similar to optical imaging with the whole-animal imaging capability of ultrasound readout.
- Photoswitching: This will resolve signals from single labeled cells from deep within live tissue.
This combination will achieve volume sampling abilities surpassing any optical microscopy by at least three orders of magnitude (> 5 x 5 x 5 mm imaging volume).
Instrumentation Development
SWOPT will develop the necessary breakthrough instrumentation and concepts, including:
- Unique multiplexed diode illumination
- Novel ultra-wideband transducer technology
- Dedicated inversion algorithms that incorporate photoswitching in the three-dimensional reconstructions
- Uniquely tailored classes of photo-switching transgene and synthetic molecular tools
Proof of Concept
The exceptional capabilities of SWOPT will be demonstrated by proof-of-concept work resolving cellular dynamics and functions in a whole tumor in a model of renal cancer in vivo.
Expertise and Collaboration
SWOPT builds on the world-leading expertise in the following disciplines:
- OA imaging technology (Ntziachristos GER)
- Applied mathematics (Unser CH)
- Cancer metabolism (Frezza UK)
It is driven by excellent young researchers in:
- Protein-engineering (Stiel GER)
- Chemical synthesis (Szymanski NL)
Additionally, it is supported by the science-to-technology focus of ambitious high-tech SMEs (Sonaxis FRA, iThera GER).
Impact and Future Aspirations
SWOPT's uniquely comprehensive, yet detailed imaging will enable examination of whole tissues in vivo with the same ease, flexibility, and, eventually, abundance of tools paralleling fluorescence microscopy. This advancement aims to bring research and understanding of living organisms to the next level.
As an affordable imaging technology, SWOPT aspires to become routine in life science and biomedical research.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 3.536.935 |
| Totale projectbegroting | € 3.536.935 |
Tijdlijn
| Startdatum | 1-9-2022 |
| Einddatum | 31-8-2026 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBHpenvoerder
- SONAXIS
- ACADEMISCH ZIEKENHUIS GRONINGEN
- KLINIKUM DER UNIVERSITAET ZU KOELN
- ITHERA MEDICAL GMBH
- IDRYMA TECHNOLOGIAS KAI EREVNAS
- ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Land(en)
Vergelijkbare projecten binnen EIC Pathfinder
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
ADAPTIVE OPTICAL METASURFACES FOR REAL-TIME, LABEL-FREE AND NON-DESTRUCTIVE 7D DIGITAL PATHOLOGYOPTIPATH aims to revolutionize tissue diagnosis by providing real-time, non-destructive 3D imaging using advanced optical technologies and machine learning to enhance accuracy and reduce variability. | EIC Pathfinder | € 3.276.577 | 2025 | Details |
On-chip tomographic microscopy: a paraDIgm Shift for RevolUtionizing lab-on-a-chiP bioimaging technologyDISRUPT aims to revolutionize biomedical imaging with a novel lab-on-chip technology for cost-effective, high-resolution cancer detection and diagnostics using integrated tomographic microscopy and AI. | EIC Pathfinder | € 3.018.312 | 2022 | Details |
MULTIMODE NONLINEAR FIBER BASED ENDOSCOPIC IMAGING AND TREATMENTMULTISCOPE aims to revolutionize optical diagnostics and therapy by developing a dual-function endoscopic device for real-time optical biopsy and cold atmospheric plasma treatment in gastrointestinal care. | EIC Pathfinder | € 2.863.733 | 2024 | Details |
Bioorthogonal Implantable Iontronic Switch to Temporally Control the Local Release of ChemotherapeuticsThe project aims to develop an implantable bioSWITCH for on-demand drug delivery to tumors, enhancing treatment efficacy and survival rates in pancreatic cancer. | EIC Pathfinder | € 4.420.511 | 2023 | Details |
Breaking the Resolution Limit in Two-Photon Microscopy Using Negative PhotochromismThis project aims to develop a novel multiphoton microscopy technique that achieves four-photon-like spatial resolution using two-photon absorption, enhancing biomedical imaging capabilities. | EIC Pathfinder | € 2.266.125 | 2023 | Details |
ADAPTIVE OPTICAL METASURFACES FOR REAL-TIME, LABEL-FREE AND NON-DESTRUCTIVE 7D DIGITAL PATHOLOGY
OPTIPATH aims to revolutionize tissue diagnosis by providing real-time, non-destructive 3D imaging using advanced optical technologies and machine learning to enhance accuracy and reduce variability.
On-chip tomographic microscopy: a paraDIgm Shift for RevolUtionizing lab-on-a-chiP bioimaging technology
DISRUPT aims to revolutionize biomedical imaging with a novel lab-on-chip technology for cost-effective, high-resolution cancer detection and diagnostics using integrated tomographic microscopy and AI.
MULTIMODE NONLINEAR FIBER BASED ENDOSCOPIC IMAGING AND TREATMENT
MULTISCOPE aims to revolutionize optical diagnostics and therapy by developing a dual-function endoscopic device for real-time optical biopsy and cold atmospheric plasma treatment in gastrointestinal care.
Bioorthogonal Implantable Iontronic Switch to Temporally Control the Local Release of Chemotherapeutics
The project aims to develop an implantable bioSWITCH for on-demand drug delivery to tumors, enhancing treatment efficacy and survival rates in pancreatic cancer.
Breaking the Resolution Limit in Two-Photon Microscopy Using Negative Photochromism
This project aims to develop a novel multiphoton microscopy technique that achieves four-photon-like spatial resolution using two-photon absorption, enhancing biomedical imaging capabilities.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
From Research Optoacoustic Novelty To Imaging Established in Routine diagnosticsFRONTIER aims to translate the innovative MSOT technology into routine clinical imaging, enhancing disease diagnosis and treatment monitoring for clinicians globally. | EIC Accelerator | € 2.451.121 | 2022 | Details |
FunctIonal optoacousticS for imaging Early onsEt of Gut inflammationThis project aims to develop functionalized contrast agents for multispectral optoacoustic tomography to enable non-invasive early detection of gastrointestinal inflammation. | ERC Starting... | € 1.453.730 | 2023 | Details |
All-optical photoacoustic imaging for neurobiologyDeveloping advanced sensors for high-speed, high-sensitivity photoacoustic imaging to non-invasively capture single-neuron activity deep in the mouse brain. | ERC Starting... | € 1.499.667 | 2024 | Details |
Method for Integrated All-Optical Biological Analysis at ScaleDeveloping an all-optical platform for precise optogenetic probing and automated data analysis to enhance research in neuroscience, developmental biology, and cancer. | ERC Proof of... | € 150.000 | 2024 | Details |
Single-Molecule Acousto-Photonic NanofluidicsSIMPHONICS aims to develop a high-throughput, non-invasive platform for protein fingerprinting by integrating nanopore technology with acoustic manipulation and fluorescence detection. | ERC Starting... | € 1.499.395 | 2022 | Details |
From Research Optoacoustic Novelty To Imaging Established in Routine diagnostics
FRONTIER aims to translate the innovative MSOT technology into routine clinical imaging, enhancing disease diagnosis and treatment monitoring for clinicians globally.
FunctIonal optoacousticS for imaging Early onsEt of Gut inflammation
This project aims to develop functionalized contrast agents for multispectral optoacoustic tomography to enable non-invasive early detection of gastrointestinal inflammation.
All-optical photoacoustic imaging for neurobiology
Developing advanced sensors for high-speed, high-sensitivity photoacoustic imaging to non-invasively capture single-neuron activity deep in the mouse brain.
Method for Integrated All-Optical Biological Analysis at Scale
Developing an all-optical platform for precise optogenetic probing and automated data analysis to enhance research in neuroscience, developmental biology, and cancer.
Single-Molecule Acousto-Photonic Nanofluidics
SIMPHONICS aims to develop a high-throughput, non-invasive platform for protein fingerprinting by integrating nanopore technology with acoustic manipulation and fluorescence detection.