Method for Integrated All-Optical Biological Analysis at Scale
Developing an all-optical platform for precise optogenetic probing and automated data analysis to enhance research in neuroscience, developmental biology, and cancer.
Projectdetails
Introduction
The advent of light-emitting sensors and light-driven actuators has profoundly transformed the fields of biology and medical science over the past three decades. These innovations enable the manipulation and monitoring of various physiological processes using light with remarkable precision in both time and space.
Applications
Applications include:
- The study of signaling and cell trafficking in healthy and malignant tissues.
- The unraveling of causal relationships within neural networks.
- Assessing the effects of pharmaceutical compounds.
Need for Integrated Optical Systems
To fully harness the potential of these so-called optogenetic technologies, there is a pressing need to create integrated optical systems offering both 3D imaging and precise light-targeting of specific regions at scale.
Project Overview
Within the framework of the ERC, we have successfully engineered a unique system designed for the optogenetic probing of small vertebrate brains (zebrafish larvae) at cellular resolution. Our proposal expands upon this earlier achievement by evolving it into a versatile all-optical platform tailored for biologists and biomedical laboratories.
Platform Features
This platform will seamlessly integrate:
- Cutting-edge optical systems.
- Automated data analysis through artificial intelligence (AI) techniques.
Anticipated Impact
Anticipating a vast array of applications, we envision that this platform will prove invaluable in the realms of neuroscience, developmental biology, and cancer research. Its multifaceted capabilities will empower researchers to unlock new insights and accelerate advancements in these critical scientific domains.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 150.000 |
Totale projectbegroting | € 150.000 |
Tijdlijn
Startdatum | 1-10-2024 |
Einddatum | 31-3-2026 |
Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- SORBONNE UNIVERSITEpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
measuriNg nEURal dynamics with label-free OpticaL multI-DomAin RecordingsThis project aims to innovate label-free optical methods for monitoring neural dynamics in the brain, enhancing understanding and treatment of brain diseases without exogenous reporters. | ERC Starting... | € 1.634.825 | 2025 | Details |
A two-photon compound fiberscope to study the brain at all spatial and temporal scales.Developing a novel 2P compound fiberscope to enable imaging and manipulation of neuronal circuits in freely moving animals, enhancing our understanding of brain function and behavior. | ERC Starting... | € 1.708.614 | 2024 | Details |
Optical imaging platform for high-throughput longitudinal studies of the eye in disease modelsThe OPTIMEYEZ project aims to enhance a novel multi-contrast optical imaging platform for non-invasive retinal studies, facilitating drug development in neurological diseases while reducing animal use. | ERC Proof of... | € 150.000 | 2023 | Details |
A light-efficient microscope for fast volumetric imaging of photon starved samplesLowLiteScope aims to revolutionize bioluminescence microscopy by using AI-driven light field techniques for high-resolution 3D imaging of biological samples, enhancing research capabilities in life sciences. | ERC Proof of... | € 150.000 | 2024 | Details |
A sonogenetic brain-machine interface for neurosciences and visual restorationDeveloping a novel sonogenetic brain-machine interface for remote, precise control of neuronal networks in large primate brains to advance treatments for neurological disorders. | ERC Synergy ... | € 7.817.939 | 2024 | Details |
measuriNg nEURal dynamics with label-free OpticaL multI-DomAin Recordings
This project aims to innovate label-free optical methods for monitoring neural dynamics in the brain, enhancing understanding and treatment of brain diseases without exogenous reporters.
A two-photon compound fiberscope to study the brain at all spatial and temporal scales.
Developing a novel 2P compound fiberscope to enable imaging and manipulation of neuronal circuits in freely moving animals, enhancing our understanding of brain function and behavior.
Optical imaging platform for high-throughput longitudinal studies of the eye in disease models
The OPTIMEYEZ project aims to enhance a novel multi-contrast optical imaging platform for non-invasive retinal studies, facilitating drug development in neurological diseases while reducing animal use.
A light-efficient microscope for fast volumetric imaging of photon starved samples
LowLiteScope aims to revolutionize bioluminescence microscopy by using AI-driven light field techniques for high-resolution 3D imaging of biological samples, enhancing research capabilities in life sciences.
A sonogenetic brain-machine interface for neurosciences and visual restoration
Developing a novel sonogenetic brain-machine interface for remote, precise control of neuronal networks in large primate brains to advance treatments for neurological disorders.
Vergelijkbare projecten uit andere regelingen
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
Insect-Brain inspired Neuromorphic NanophotonicsDeveloping nanophotonic chips inspired by insect brains for energy-efficient autonomous navigation and neuromorphic computing, integrating sensing and processing capabilities. | EIC Pathfinder | € 3.229.534 | 2022 | Details |
Development of an In-Vivo Brillouin Microscope (with application to Protein Aggregation-based Pathologies)This project aims to enhance Brillouin Microscopy for real-time, non-destructive assessment of viscoelastic properties in living cells, addressing key biomedical challenges. | EIC Pathfinder | € 3.333.513 | 2023 | Details |
ADAPTIVE OPTICAL METASURFACES FOR REAL-TIME, LABEL-FREE AND NON-DESTRUCTIVE 7D DIGITAL PATHOLOGYOPTIPATH aims to revolutionize tissue diagnosis by providing real-time, non-destructive 3D imaging using advanced optical technologies and machine learning to enhance accuracy and reduce variability. | EIC Pathfinder | € 3.276.577 | 2025 | Details |
Insect-Brain inspired Neuromorphic Nanophotonics
Developing nanophotonic chips inspired by insect brains for energy-efficient autonomous navigation and neuromorphic computing, integrating sensing and processing capabilities.
Development of an In-Vivo Brillouin Microscope (with application to Protein Aggregation-based Pathologies)
This project aims to enhance Brillouin Microscopy for real-time, non-destructive assessment of viscoelastic properties in living cells, addressing key biomedical challenges.
ADAPTIVE OPTICAL METASURFACES FOR REAL-TIME, LABEL-FREE AND NON-DESTRUCTIVE 7D DIGITAL PATHOLOGY
OPTIPATH aims to revolutionize tissue diagnosis by providing real-time, non-destructive 3D imaging using advanced optical technologies and machine learning to enhance accuracy and reduce variability.