Hybrid Electrochemically-paired Light Irradiated Organic Synthesis

HELIOS aims to develop paired synthetic photoelectrochemical reactions to efficiently convert abundant feedstocks into valuable complex molecules while enhancing sustainability and selectivity.

Subsidie
€ 1.499.828
2023

Projectdetails

Introduction

The synergy of visible light and electrical energy has been employed for decades in water splitting to hydrogen, but only recently was it used to power the synthesis of higher value complex organic molecules (natural products, pharmaceuticals).

Synthetic Photoelectrochemistry

Synthetic photoelectrochemistry (PEC) is receiving notable attention due to its enhanced scope of redox transformations, sustainability, and selectivity compared to photo- or electrochemistry alone.

Synthetic Electrochemistry

Synthetic electrochemistry (EC) is a useful synthetic tool that replaces atom-uneconomical chemical redox agents with simple electrons and protons. However, in most EC reactions and in all PEC reactions, only one half-reaction of the cell is optimized to generate value; the other half-reaction sacrifices its own electrode or redox additives.

Paired Electrolysis

‘Paired’ electrolysis, where both half-reactions afford useful species, is key to sustainability and efficiency.

Project Goals

HELIOS will discover, develop, and disseminate paired synthetic PEC reactions. Intermediates generated by both half-reactions are converged in novel, creative chemical transformations, including:

  1. Marriage of radicals or ions generated by each half-reaction to furnish phenethylamines and azetidines, valued pharmaceuticals.
  2. Ring-fusing reactions that furnish bicyclic scaffolds, toward molecules with high 3D character urgently required in drug discovery.
  3. Alcohol inversion reactions that are catalytic, environmentally-friendly, and use mild conditions.

Multifunctional Catalysts

‘Multifunctional’ catalysts will be used that can be electro-activated in both cathodic and anodic half-cells, to photochemically generate and stabilize reactive intermediates.

Conclusion

HELIOS i) harnesses electrical and light energy to rapidly convert cheap, abundant chemical feedstocks to value-added complex molecules and ii) improves the sustainability and selectivity of synthetic PEC and EC processes. HELIOS opens an entirely new dimension of chemical reactivity that will revolutionize the way chemists use redox to synthesize molecules.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 1.499.828
Totale projectbegroting€ 1.499.828

Tijdlijn

Startdatum1-11-2023
Einddatum31-10-2028
Subsidiejaar2023

Partners & Locaties

Projectpartners

  • UNIVERSITAET REGENSBURGpenvoerder

Land(en)

Germany

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