Biodegradable MEMS implants for nerve repair
Develop biodegradable MEMS implants for nerve repair using innovative mechanical stimulation strategies to enhance neural regeneration post-injury.
Projectdetails
Introduction
In this project, I will develop biodegradable MEMS (Micro-Electro-Mechanical Systems) implants for nerve repair, a new class of microsystems made entirely of biodegradable materials, including sensors, actuators, and electronics.
Project Focus
These wireless implants will focus on the mechanical stretching of peripheral nerves in vivo for neural regeneration after injury. Two strategies will be explored, compared, and combined:
- Cyclic mechanical nerve stimulation with NerveCyclicStretch, a soft biodegradable magnetic implant controlled by wireless magnetic actuation with an integrated strain sensor.
- Constant mechanical traction with NerveSuctionStretch, a biodegradable implant applying negative pressure to the injured nerve with a biodegradable MEMS micropump and with an integrated pressure sensor.
New biodegradable stretchable magnetic and conducting materials will be developed for this purpose. In vivo studies on the sciatic nerve of rat models will be performed to demonstrate the proper operation of the implants and to identify the optimal mechanical stimulation parameters for nerve repair.
Material Development
The development of new functional biodegradable materials (with tailored magnetic, electrical, and mechanical properties) and cleanroom-compatible fabrication processes (thin films deposition, photolithography, etching of biodegradable metals and polymer composites) will enable the realization of fully biodegradable microsystems while retaining the established advantages of MEMS:
- Small size
- High precision
- Fast response time
- Low energy consumption
- Reliable large-scale production
Impact
This proposal is a paradigm shift in the design of medical devices, with biodegradable implants allowing for the first time the in vivo exploration of a promising new therapeutic approach. Beyond neurosciences, Nerve-Repair2.0 will pave the way for many other medical applications including cardiac diseases, addressing crucial societal challenges that could not be solved otherwise.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 1.672.968 |
Totale projectbegroting | € 1.672.968 |
Tijdlijn
Startdatum | 1-11-2023 |
Einddatum | 28-2-2029 |
Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- TECHNISCHE UNIVERSITEIT DELFTpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
Injectable nanoelectrodes for wireless and minimally invasive neural stimulationDeveloping minimally invasive, nanoscale, wireless neuroelectrodes for targeted neural stimulation to improve treatment accessibility for neurological impairments. | ERC Starting... | € 1.499.725 | 2023 | Details |
Neuromorphic Flexible Electro/chemical Interface for in-Memory Bio-Sensing and Computing.Develop a miniaturized, self-contained biosensing technology using neuromorphic devices for real-time monitoring and classification of neurodegenerative biomarkers in individualized healthcare. | ERC Starting... | € 1.500.000 | 2025 | Details |
5D Electro-Mechanical Bio-Interface for Neuronal Tissue EngineeringDevelop a novel 3D biomaterial for leadless electrical and mechanical modulation to enhance brain research and neuroengineering applications. | ERC Starting... | € 1.750.000 | 2024 | Details |
Deep-Body Wireless Bioelectronics Enabled by Physics-Based Bioadaptive Wave ControlThe project aims to develop bio-adaptive wave control technologies for efficient powering and precise control of wireless bioelectronic implants in the body, enhancing medical monitoring and therapy delivery. | ERC Starting... | € 1.499.973 | 2025 | Details |
Bidirectional remote deep brain control with magnetic anisotropic nanomaterialsBRAINMASTER aims to develop a scalable, wireless neuromodulation system using magnetic nanodiscs for deep brain therapy and imaging, enhancing cognitive training and treatment for neurological disorders. | ERC Starting... | € 1.500.000 | 2024 | Details |
Injectable nanoelectrodes for wireless and minimally invasive neural stimulation
Developing minimally invasive, nanoscale, wireless neuroelectrodes for targeted neural stimulation to improve treatment accessibility for neurological impairments.
Neuromorphic Flexible Electro/chemical Interface for in-Memory Bio-Sensing and Computing.
Develop a miniaturized, self-contained biosensing technology using neuromorphic devices for real-time monitoring and classification of neurodegenerative biomarkers in individualized healthcare.
5D Electro-Mechanical Bio-Interface for Neuronal Tissue Engineering
Develop a novel 3D biomaterial for leadless electrical and mechanical modulation to enhance brain research and neuroengineering applications.
Deep-Body Wireless Bioelectronics Enabled by Physics-Based Bioadaptive Wave Control
The project aims to develop bio-adaptive wave control technologies for efficient powering and precise control of wireless bioelectronic implants in the body, enhancing medical monitoring and therapy delivery.
Bidirectional remote deep brain control with magnetic anisotropic nanomaterials
BRAINMASTER aims to develop a scalable, wireless neuromodulation system using magnetic nanodiscs for deep brain therapy and imaging, enhancing cognitive training and treatment for neurological disorders.
Vergelijkbare projecten uit andere regelingen
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
A synaptic mechanogenetic technology to repair brain connectivityDeveloping a mechanogenetic technology using magnetic nanoparticles to non-invasively regulate neural circuits for treating treatment-resistant brain disorders like stroke and epilepsy. | EIC Pathfinder | € 3.543.967 | 2023 | Details |
Ontwikkeling van een biocompatibele en bio-afbreekbare zenuwcassetteHet project onderzoekt de technische en economische haalbaarheid van een bio-afbreekbare zenuwcassette om pijnlijke neuromen na amputatie te behandelen en mobiliteitsproblemen te verhelpen. | Mkb-innovati... | € 20.000 | 2022 | Details |
BioFunctional IntraNeural ElectrodesBioFINE aims to develop advanced flexible intraneural multielectrode arrays for improved long-term integration with peripheral nerves, enhancing bionic limb communication and neurotechnology. | EIC Pathfinder | € 1.945.622 | 2023 | Details |
DRUG-ELUTING ELECTRICAL IMPLANT TO REPAIR THE SPINAL CORDDREIMS aims to advance a novel drug-eluting electrical implant for spinal cord repair by refining its design and meeting regulatory standards for human therapeutic use. | EIC Transition | € 2.494.542 | 2023 | Details |
Smart 4D biodegradable metallic shape-shifting implants for dynamic tissue restorationBIOMET4D aims to revolutionize reconstructive surgery with shape-morphing implants for dynamic tissue restoration, enhancing regeneration while reducing costs and invasiveness. | EIC Pathfinder | € 4.039.541 | 2022 | Details |
A synaptic mechanogenetic technology to repair brain connectivity
Developing a mechanogenetic technology using magnetic nanoparticles to non-invasively regulate neural circuits for treating treatment-resistant brain disorders like stroke and epilepsy.
Ontwikkeling van een biocompatibele en bio-afbreekbare zenuwcassette
Het project onderzoekt de technische en economische haalbaarheid van een bio-afbreekbare zenuwcassette om pijnlijke neuromen na amputatie te behandelen en mobiliteitsproblemen te verhelpen.
BioFunctional IntraNeural Electrodes
BioFINE aims to develop advanced flexible intraneural multielectrode arrays for improved long-term integration with peripheral nerves, enhancing bionic limb communication and neurotechnology.
DRUG-ELUTING ELECTRICAL IMPLANT TO REPAIR THE SPINAL CORD
DREIMS aims to advance a novel drug-eluting electrical implant for spinal cord repair by refining its design and meeting regulatory standards for human therapeutic use.
Smart 4D biodegradable metallic shape-shifting implants for dynamic tissue restoration
BIOMET4D aims to revolutionize reconstructive surgery with shape-morphing implants for dynamic tissue restoration, enhancing regeneration while reducing costs and invasiveness.