SubsidieMeestersSupramolecular microcapsules for bioreactor expansion of induced pluripotent stem cells
The SUPROTECT project aims to develop squaramide-based microcapsules for culturing pluripotent stem cells, evaluating their effectiveness while securing intellectual property for potential licensing.
Projectdetails
Introduction
The SUPROTECT proof-of-concept project seeks to apply our squaramide-based (SQ) supramolecular materials to prepare microcapsules for the culture of pluripotent stem cells.
Project Objectives
Building on earlier demonstrations of bioactive hydrogel synthesis and in vitro culture of iPSCs in 3D cell culture under static conditions, we will:
- Synthesize the necessary amount of material for iPSC culture studies.
- Develop protocols to prepare microcapsules with and without iPSCs.
- Evaluate the feasibility of the different microcapsules for the culture of iPSCs and their release, ranking the approaches based on iPSC number and quality for further downstream application.
Market Research
In parallel with these activities, we will perform detailed market research studies on microfabricated polymer materials for the culture of various cell types. This will involve:
- Protecting our intellectual property (IP) position.
- Consolidating our findings in a package for product licensing with the appropriate party.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-6-2024 |
| Einddatum | 30-11-2025 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSITEIT LEIDENpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
SUPRAmolecular Hydrogel Driven Assembly of Designer Heart TissuesThe SUPRAHEART project aims to develop synthetic squaramide-based hydrogels for scalable engineered heart tissues, enhancing reproducibility for pharmaceutical testing and commercialization. | ERC Proof of... | € 150.000 | 2025 | Details |
Scaling up iPSC Expansion and Differentiation using Recombinant BioemulsionsThe project aims to develop scalable, regulatory-compliant bioemulsions using engineered protein nanosheets for efficient iPSC culture and differentiation, enhancing cell manufacturing and biotech market growth. | ERC Proof of... | € 150.000 | 2025 | Details |
Advanced 3D in vitro models based on magnetically-driven docking of modular microscaffoldsThis project aims to develop 3D modular co-culture systems using magnetic microscaffolds to replicate brain tumor microenvironments for drug screening and cancer therapy testing. | ERC Proof of... | € 150.000 | 2023 | Details |
The hydrocup: a hollow electrospun scaffold for in vivo cell-laden hydrogel deliveryDeveloping a hollow electrospun scaffold for localized delivery of viable stem cells to enhance cytokine secretion and support cardiac regeneration, with plans for commercialization. | ERC Proof of... | € 150.000 | 2022 | Details |
Custom-Made Designer Macrophages to Revolutionize the Safety of Parenteral DrugsiPYRO aims to revolutionize drug safety evaluations by developing a standardized, economically produced macrophage-based cell product from iPSC, ensuring regulatory compliance and industry readiness. | ERC Proof of... | € 150.000 | 2023 | Details |
SUPRAmolecular Hydrogel Driven Assembly of Designer Heart Tissues
The SUPRAHEART project aims to develop synthetic squaramide-based hydrogels for scalable engineered heart tissues, enhancing reproducibility for pharmaceutical testing and commercialization.
Scaling up iPSC Expansion and Differentiation using Recombinant Bioemulsions
The project aims to develop scalable, regulatory-compliant bioemulsions using engineered protein nanosheets for efficient iPSC culture and differentiation, enhancing cell manufacturing and biotech market growth.
Advanced 3D in vitro models based on magnetically-driven docking of modular microscaffolds
This project aims to develop 3D modular co-culture systems using magnetic microscaffolds to replicate brain tumor microenvironments for drug screening and cancer therapy testing.
The hydrocup: a hollow electrospun scaffold for in vivo cell-laden hydrogel delivery
Developing a hollow electrospun scaffold for localized delivery of viable stem cells to enhance cytokine secretion and support cardiac regeneration, with plans for commercialization.
Custom-Made Designer Macrophages to Revolutionize the Safety of Parenteral Drugs
iPYRO aims to revolutionize drug safety evaluations by developing a standardized, economically produced macrophage-based cell product from iPSC, ensuring regulatory compliance and industry readiness.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
SBMP - disrupting the manufacturing of biological drugs through a ground-breaking nanotechnology-based microcarrierCellevate's SBMP-microcarriers use innovative nanofibrous technology to enhance adherent cell culture in bioreactors, significantly improving biopharmaceutical production efficiency and quality. | EIC Accelerator | € 2.485.857 | 2022 | Details |
PRInted Symbiotic Materials as a dynamic platform for Living Tissues productionPRISM-LT aims to develop a flexible bioprinting platform using hybrid living materials to enhance stem cell differentiation with engineered helper cells for biomedical and food applications. | EIC Pathfinder | € 2.805.403 | 2022 | Details |
INTELLIGENT ENCAPSULATION AND SCREENING PLATFORM FOR PRECISION DELIVERY OF PROBIOTICS TO IMPROVE GUT HEALTHiNSIGHT aims to develop precision probiotics through innovative microencapsulation for targeted delivery, enhancing gut health and addressing related diseases using advanced technology and personalized treatment. | EIC Pathfinder | € 3.194.343 | 2025 | Details |
Rapid Interventional Stem cells Platform 2.0 (RISP)Dit project richt zich op de ontwikkeling en validatie van een modulair, op afstand bestuurbaar platform voor de veilige productie en kwaliteitscontrole van (stam)celproducten, met als doel wereldwijde distributie. | Mkb-innovati... | € 180.430 | 2018 | Details |
AI-powered platform for autologous iPSC manufacturingThe project aims to develop an AI-guided microfluidic device for the standardized, cost-effective mass production of personalized iPSCs to enhance cancer therapies and tissue regeneration. | EIC Pathfinder | € 3.999.225 | 2022 | Details |
SBMP - disrupting the manufacturing of biological drugs through a ground-breaking nanotechnology-based microcarrier
Cellevate's SBMP-microcarriers use innovative nanofibrous technology to enhance adherent cell culture in bioreactors, significantly improving biopharmaceutical production efficiency and quality.
PRInted Symbiotic Materials as a dynamic platform for Living Tissues production
PRISM-LT aims to develop a flexible bioprinting platform using hybrid living materials to enhance stem cell differentiation with engineered helper cells for biomedical and food applications.
INTELLIGENT ENCAPSULATION AND SCREENING PLATFORM FOR PRECISION DELIVERY OF PROBIOTICS TO IMPROVE GUT HEALTH
iNSIGHT aims to develop precision probiotics through innovative microencapsulation for targeted delivery, enhancing gut health and addressing related diseases using advanced technology and personalized treatment.
Rapid Interventional Stem cells Platform 2.0 (RISP)
Dit project richt zich op de ontwikkeling en validatie van een modulair, op afstand bestuurbaar platform voor de veilige productie en kwaliteitscontrole van (stam)celproducten, met als doel wereldwijde distributie.
AI-powered platform for autologous iPSC manufacturing
The project aims to develop an AI-guided microfluidic device for the standardized, cost-effective mass production of personalized iPSCs to enhance cancer therapies and tissue regeneration.