AI-powered platform for autologous iPSC manufacturing

The project aims to develop an AI-guided microfluidic device for the standardized, cost-effective mass production of personalized iPSCs to enhance cancer therapies and tissue regeneration.

Subsidie
€ 3.999.225
2022

Projectdetails

Introduction

Induced pluripotent stem cells (iPSCs) can be differentiated into any cell type of the body and transplanted without rejection. The potential of iPSCs to cure health problems including degenerative diseases, cancer, cancer therapy-associated diseases, and defective tissues is unprecedented in history. However, the current methodologies prohibit standardized production of a person's own (autologous) iPSCs; hence rejection is taking place and the therapeutic promise is not fulfilled.

Project Objectives

Our consortium seeks to develop a new technology that will enable the mass production of personalized iPSCs for:

  1. Autologous adoptive cancer immunotherapies
  2. Hematopoietic stem cell transplantation
  3. Tissue regeneration

Innovative Technology

The consortium will, for the first time, create an artificial intelligence (AI) guided microfluidic device that:

  • Standardizes the GMP production of autologous iPSCs
  • Produces them quickly and at a fraction of the current cost

Moreover, it will conduct cutting-edge single-cell genomics and bioinformatics research of iPSCs to identify clones of the highest quality. This research will lead to the development of a database that will serve as the basis for AI software to select clones that meet clinical standards.

Consortium Expertise

The consortium comprises experts in:

  • Microfluidics engineering
  • Process automation for cell therapies
  • Stem cell molecular biology and bioinformatics
  • GMP production
  • AI modeling

The participating companies, startups, and universities are among the leading entities in Europe. They will promote the positions of female and early career participants from both developed and developing European countries.

Goals and Implementation

The consortium aims to reach the TRL3 prototype stage and has created a concrete exploitation plan to develop the technology further for implementation in cancer therapy and regenerative medicine.

Conclusion

Altogether, we propose to create revolutionary technology for low-cost, fast, and standardized automated mass production of autologous iPSCs. This holds the potential to enable numerous new therapies and make them accessible to the public.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 3.999.225
Totale projectbegroting€ 3.999.225

Tijdlijn

Startdatum1-9-2022
Einddatum31-8-2026
Subsidiejaar2022

Partners & Locaties

Projectpartners

  • MIDA BIOTECH BVpenvoerder
  • DEEPPATH MONOPROSOPI I.K.E
  • UNIVERSITEIT LEIDEN
  • MIRCOD
  • BIT BIO DISCOVERY GMBH

Land(en)

NetherlandsGreeceLatviaAustria

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