SubsidieMeestersSingle-Cell Metabolomics for Drug Discovery and Development
The project aims to commercialize single-cell metabolomics technology to enhance drug safety by revealing off-target effects and metabolic responses in drug candidates.
Projectdetails
Introduction
Despite the major efforts in modern drug discovery and development, the field is still in its crisis with productivity increasingly declining. A major source of drug development failure is toxicity, where the adverse drug reaction is often caused by off-target effects of drug candidates that can be revealed only late in the drug development process.
Metabolomics as a Solution
Metabolomics has been proposed as an emerging promising approach to monitor off-target effects on metabolic enzymes or transporters, thus providing mechanistic understanding of drug toxicity. However, there are multiple challenges in applying metabolomics in this context, including:
- The inability to resolve the drug metabolic response on the single-cell level.
Project Proposal
In this PoC project, we propose to commercialize the technology of single-cell metabolomics developed in the ERC CoG project METACELL. Specifically, we propose using our single-cell metabolomics technology in conjunction with the data-driven metabolic modulation approach for:
- Revealing single-cell metabolic response
- Understanding the metabolic mode of action of drugs and drug candidates.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-11-2022 |
| Einddatum | 30-4-2024 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- EUROPEAN MOLECULAR BIOLOGY LABORATORYpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
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|---|---|---|---|---|
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High-throughput combinatory drugs testing on in vitro 3D cells model platformThe project aims to develop a microfluidic platform for high-throughput screening of drug combinations in 3D cultures to enhance drug discovery and identify synergistic therapies for breast cancer. | ERC Proof of... | € 150.000 | 2023 | Details |
Multidimensional in vivo metabolic flux analyses: Resolving immune cells based on in vivo metabolic phenotypes
The project aims to develop a novel nutrient uptake assay for analyzing immune cell metabolism in vivo, enhancing immunotherapy design for solid tumors through detailed metabolic insights.
Learning and modeling the molecular response of single cells to drug perturbations
DeepCell aims to model cellular responses to drug perturbations using multiomics and deep learning, facilitating optimal treatment design and expediting drug discovery in clinical settings.
Revealing cellular behavior with single-cell multi-omics
Develop a single-cell multi-omics approach to analyze β-cell heterogeneity and metabolism, aiming to uncover insights into diabetes-related dysfunction and potential treatment targets.
Capturing tumoral drug metabolism by Cells In the Tissue Environment using spatial pharmacometabolomics
The CITE project aims to develop innovative analytical technologies to study intratumoral drug metabolism in pancreatic cancer, enhancing understanding of treatment resistance mechanisms.
High-throughput combinatory drugs testing on in vitro 3D cells model platform
The project aims to develop a microfluidic platform for high-throughput screening of drug combinations in 3D cultures to enhance drug discovery and identify synergistic therapies for breast cancer.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Simultaneous Multiparametric MEA based platform for in-vitro chronic cardiotoxicity assessment with live-cell fluorescence imaging and electrophysiology.SiMulTox develops a novel platform for simultaneous long-term assessment of functional and structural cardiotoxicity, aiming to enhance drug safety evaluation and reshape the in-vitro testing market. | EIC Transition | € 786.875 | 2022 | Details |
Functional Cell SorterDit project richt zich op het karakteriseren en sorteren van individuele cellen op functie om moleculaire eigenschappen te koppelen, wat de ontwikkeling van medicijnen en ziekteonderzoek bevordert. | Mkb-innovati... | € 185.500 | 2017 | Details |
Universal GPCR Activity Sensor for Next Generation Drug DiscoveryThis project aims to develop a novel single-assay technology platform for GPCR drug discovery, enhancing detection and classification of drug candidates to improve efficacy and reduce failures. | EIC Pathfinder | € 2.965.384 | 2023 | Details |
A multiplexed biomimetic imaging platform for assessing single cell plasticity (Plastomics) and scoring of tumour malignancyThe PLAST_CELL project aims to develop a microfluidics-based imaging platform to quantify cancer cell plasticity, enhancing diagnosis and treatment of metastasis and therapy resistance. | EIC Pathfinder | € 2.982.792 | 2022 | Details |
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Simultaneous Multiparametric MEA based platform for in-vitro chronic cardiotoxicity assessment with live-cell fluorescence imaging and electrophysiology.
SiMulTox develops a novel platform for simultaneous long-term assessment of functional and structural cardiotoxicity, aiming to enhance drug safety evaluation and reshape the in-vitro testing market.
Functional Cell Sorter
Dit project richt zich op het karakteriseren en sorteren van individuele cellen op functie om moleculaire eigenschappen te koppelen, wat de ontwikkeling van medicijnen en ziekteonderzoek bevordert.
Universal GPCR Activity Sensor for Next Generation Drug Discovery
This project aims to develop a novel single-assay technology platform for GPCR drug discovery, enhancing detection and classification of drug candidates to improve efficacy and reduce failures.
A multiplexed biomimetic imaging platform for assessing single cell plasticity (Plastomics) and scoring of tumour malignancy
The PLAST_CELL project aims to develop a microfluidics-based imaging platform to quantify cancer cell plasticity, enhancing diagnosis and treatment of metastasis and therapy resistance.
Magnetic Resonance at the Scale of a Cell
The HyperCell project aims to revolutionize cell research by developing a non-invasive benchtop tool for single-cell metabolic analysis, enhancing understanding of diseases and treatment responses.