Bidirectional neuromuscular interface based on associative plasticity for stroke therapy during activities of daily living

Introduction

Stroke is a leading cause of disability globally, with millions affected each year. A critical challenge in stroke recovery is the limited availability and intensity of rehabilitation therapies, which often fail to meet recommended guidelines.

Project Overview

The neubond device aims to address this by delivering autonomous, wearable therapy to stroke survivors during their daily activities. The device detects muscle activity through muscle signals and provides real-time stimulation to enhance motor recovery.

Innovative Approach

By leveraging our novel volition induced paired associative stimulation (VIPAS) approach, the system stimulates neuroplasticity and facilitates muscle contractions, accelerating functional improvements without the need for complex setups or screen-based exercises.

Initial Trials

Initial trials have demonstrated significant improvements in motor function and usability, with:

1. A reduction in spasticity
2. Increased range of motion

Alignment with Needs

Our concept aligns with the unmet need for continuous, accessible rehabilitation, bridging the gap between clinical and home-based care. The device's non-invasive, autonomous design enhances patient compliance, ensuring consistent therapy outside of scheduled sessions.

Research Background

The project leverages findings from the ERC Synergy grant Natural BionicS, focusing on bi-directional brain-muscle interfaces.

Future Goals

The project aims to advance the prototype towards regulatory compliance, safety, and usability testing, ultimately driving commercialization and spinout formation.

Potential Impact

Our device presents a high-gain potential, with significant cost savings for healthcare providers and enhanced quality of life for stroke survivors.