Next-gen ultrasound imaging by closing the perception-action loop
This project aims to revolutionize ultrasound imaging by integrating intelligent autonomous agents that utilize probabilistic inference for enhanced image quality and effective data acquisition.
Projectdetails
Introduction
Ultrasound (US) can revolutionize and democratize medical imaging if it offers:
- Access for everyone, and
- Excellent Image Quality (IQ).
MRI offers excellent Image Quality but is expensive and will thus not likely be able to provide access for everyone. Low-cost US hardware technology will enable access in the future but is not expected to yield the needed breakthrough for excellent Image Quality. Consequently, any paradigm-shifting advance in signal processing technology that achieves US with excellent IQ will have a huge impact.
Proposed Approach
I propose a conceptually new and highly unconventional approach that I believe can lead to a new generation of US technologies with excellent IQ. I will formally describe US systems as intelligent autonomous agents that perform actions and perception using probabilistic inference:
- The action is the acquisition, probing the world, and
- The perception is the reconstruction that infers what anatomy most likely generated the acquired US data.
Current Limitations
I conclude that current US systems are in essence flawed agents since:
- Actions are not driven by perception, i.e., the perception-action loop is broken, and
- Their generative perception models are naive.
My proposal will address this by closing the perception-action loop and offering strong perception models based on advanced deep generative networks. This breaks a fundamental tenet in US imaging, where I put forth the important concept that the acquisition and perception should work together to identify the point on the low-dimensional manifold of pure anatomy (described by the generative model) that is being imaged.
Intelligent US Agents
My intelligent US agents will pursue excellent IQ under the heading of a single probabilistic principle: minimization of "surprise" under the agent’s own prior belief (the generative model) that such high-quality images can indeed be achieved.
With this, we open a new frontier within active imaging (in US and beyond) where data acquisition and information processing are treated jointly based on expressive generative density functions.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 1.812.500 |
Totale projectbegroting | € 1.812.500 |
Tijdlijn
Startdatum | 1-4-2023 |
Einddatum | 31-3-2028 |
Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- TECHNISCHE UNIVERSITEIT EINDHOVENpenvoerder
Land(en)
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Cloud-native ultrasound imaging
CloudSound aims to revolutionize ultrasound imaging by leveraging cloud computing for high-quality, affordable, and accessible medical imaging through a closed-loop, goal-directed approach.
A sonogenetic brain-machine interface for neurosciences and visual restoration
Developing a novel sonogenetic brain-machine interface for remote, precise control of neuronal networks in large primate brains to advance treatments for neurological disorders.
Remote controlling biological systems by sonopharmacology and sonogenetics
This project aims to develop biocompatible ultrasound technology to control drug, protein, and gene activity, enhancing therapies for cancer, diabetes, and tissue engineering while minimizing side effects.
Intelligent Optoacoustic Radiomics via Synergistic Integration of System Models and Medical Knowledge
EchoLux aims to revolutionize radiomics by integrating imaging hardware, medical knowledge, and Bayesian reasoning for explainable diagnostics in optoacoustic imaging of peripheral neuropathy.
All-optical photoacoustic imaging for neurobiology
Developing advanced sensors for high-speed, high-sensitivity photoacoustic imaging to non-invasively capture single-neuron activity deep in the mouse brain.
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AEGEUS - A Novel EEG Ultrasound Device for Functional Brain Imaging and NeurostimulationDevelop a novel wearable device combining ultrasound imaging and EEG for enhanced diagnosis and treatment of neurological disorders, aiming for improved patient outcomes and research advancements. | EIC Pathfinder | € 2.998.988 | 2023 | Details |
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Closed-loop Individualized image-guided Transcranial Ultrasonic StimulationThe project aims to develop a neuronavigated transcranial ultrasound stimulation (TUS) system for precise, non-invasive modulation of deep brain structures to treat neurological and psychiatric disorders. | EIC Pathfinder | € 3.799.402 | 2022 | Details |
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Quantitative Ultrasound Stochastic Tomography - Revolutionizing breast cancer diagnosis and screening with supercomputing-based radiation-free imaging.
The project aims to revolutionize breast cancer imaging by developing adjoint-based algorithms for uncertainty quantification, enhancing diagnostic confidence through high-resolution, radiation-free images.
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Develop a novel wearable device combining ultrasound imaging and EEG for enhanced diagnosis and treatment of neurological disorders, aiming for improved patient outcomes and research advancements.
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Closed-loop Individualized image-guided Transcranial Ultrasonic Stimulation
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