Technology Of Protein delivery in Extracellular Vesicle-induced Cardiac Repair
TOP-EVICARE aims to enhance cardiac repair in heart failure by developing innovative protein loading systems in extracellular vesicles, ensuring effective delivery and commercialization.
Projectdetails
Introduction
More than 3.5 million people are newly diagnosed with heart failure every year in Europe, with a long-term prognosis of 50% mortality within 4 years. There is a major need for more innovative, regenerative therapies that have the potential to change the course of the disease.
Project Overview
In the ERC-Extracellular Vesicle-Inspired CArdiac REpair (EVICARE), I hypothesized that we can recondition heart failure by stimulating cardiac repair with extracellular vesicles that are derived from progenitor cells. From the EVICARE application results, however, we realized that enhancing the therapeutic load of EVs will enhance their functional effect size to treat chronic diseases.
In TOP-EVICARE (Technology Of Protein delivery in Extracellular Vesicle-induced Cardiac Repair), I aim to explore active loading and release systems that will allow protein therapeutic loading in extracellular vesicles to stimulate myocardial repair.
Project Objectives
Within this project, I aim to:
- Validate our innovative EV-loading strategy by assessing biodistribution and functional delivery in vivo, and exploring the potential for upscaling GMP production to meet industry standards and requirements.
- Conduct a comprehensive intellectual property (IP) landscape analysis to establish freedom-to-operate (FTO) and ensure that our technology can be commercialized without infringing on existing patents.
- Execute an in-depth market, competitor, and stakeholder analysis to identify strategic opportunities and potential challenges in the EV-based therapeutic landscape.
- Develop a robust and detailed business plan to effectively guide the commercialization of our loading technology, thus bringing a transformative solution to the treatment of various diseases.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 150.000 |
Totale projectbegroting | € 150.000 |
Tijdlijn
Startdatum | 1-10-2023 |
Einddatum | 31-3-2025 |
Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- UNIVERSITAIR MEDISCH CENTRUM UTRECHTpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
Harnessing Novel Micropeptides in Cardiomyocytes to promote Cardiac RegenerationNovel.CaRe aims to enhance cardiac regeneration post-myocardial infarction by using micropeptides to stimulate cardiomyocyte proliferation and maturation through innovative gene therapy approaches. | ERC Starting... | € 1.592.281 | 2024 | Details |
Reliable and scalable procedures for the isolation and loading of extracellular vesiclesLABORIOUS aims to develop innovative methods for isolating and loading therapeutic agents into exosomes, enhancing their clinical application in various diseases while minimizing membrane damage. | ERC Proof of... | € 150.000 | 2024 | Details |
High-Throughput Production of Extracellular Vesicles from Organoids under Rotating MotionThe project aims to develop a streamlined system for high-throughput production of extracellular vesicles (EVs) by integrating controlled cell configurations to enhance therapeutic potential. | ERC Proof of... | € 150.000 | 2024 | Details |
Redesigning aortic endograft: enabling in-situ personalized aneurysm healingEPEIUS aims to revolutionize aortic aneurysm treatment by developing a bioengineered, 3D-printed, drug-loaded endograft for early personalized healing through innovative in-vitro models. | ERC Consolid... | € 1.991.225 | 2024 | Details |
Unravelling extracellular vesicle heterogeneity to inspire improved therapeutic RNA delivery systemsUNRAVEL aims to characterize extracellular vesicle subpopulations for enhanced RNA delivery, leading to the development of biomimetic synthetic RNA delivery systems to improve therapeutic applications. | ERC Consolid... | € 2.000.000 | 2025 | Details |
Harnessing Novel Micropeptides in Cardiomyocytes to promote Cardiac Regeneration
Novel.CaRe aims to enhance cardiac regeneration post-myocardial infarction by using micropeptides to stimulate cardiomyocyte proliferation and maturation through innovative gene therapy approaches.
Reliable and scalable procedures for the isolation and loading of extracellular vesicles
LABORIOUS aims to develop innovative methods for isolating and loading therapeutic agents into exosomes, enhancing their clinical application in various diseases while minimizing membrane damage.
High-Throughput Production of Extracellular Vesicles from Organoids under Rotating Motion
The project aims to develop a streamlined system for high-throughput production of extracellular vesicles (EVs) by integrating controlled cell configurations to enhance therapeutic potential.
Redesigning aortic endograft: enabling in-situ personalized aneurysm healing
EPEIUS aims to revolutionize aortic aneurysm treatment by developing a bioengineered, 3D-printed, drug-loaded endograft for early personalized healing through innovative in-vitro models.
Unravelling extracellular vesicle heterogeneity to inspire improved therapeutic RNA delivery systems
UNRAVEL aims to characterize extracellular vesicle subpopulations for enhanced RNA delivery, leading to the development of biomimetic synthetic RNA delivery systems to improve therapeutic applications.
Vergelijkbare projecten uit andere regelingen
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
A revolutionary technology platform for providing life-saving treatment for end-stage heart failure patientsreBEAT is an innovative heart support technology that safely assists both sides of the heart, aiming to improve treatment accessibility and cost-effectiveness for end-stage heart failure patients. | EIC Accelerator | € 2.499.999 | 2023 | Details |
Transcatheter Ventricular Repair Device for treatment of Heart Failure PatientsCardiac Success aims to develop the V-sling, a transcatheter device to enhance heart function in heart failure patients, through product optimization and pre-clinical testing. | EIC Accelerator | € 2.500.000 | 2022 | Details |
TowArd demoCRatization Of ev-BAsed TherapiesEVerZom aims to revolutionize EV manufacturing with a patented scalable process, targeting GMP compliance and commercial production to lead the European market in clinical applications. | EIC Accelerator | € 1.700.000 | 2022 | Details |
Recombinant fibrinogen for extravascular support (EVS) after vein bypass graftingFibriant BV ontwikkelt een kosteneffectieve, recombinant fibrinogeenvariant voor extravasculaire steun bij bypass chirurgie om afsluiting van getransplanteerde aderen te verminderen. | Mkb-innovati... | € 315.100 | 2015 | Details |
Prefabricated Mature Blood Vessels and Tools for Vascularized 3D Cell CultureThe Vasc-on-Demand project aims to develop three innovative products for easy generation of vascularized 3D tissues, enhancing research and drug testing while reducing reliance on animal trials. | EIC Transition | € 2.488.750 | 2024 | Details |
A revolutionary technology platform for providing life-saving treatment for end-stage heart failure patients
reBEAT is an innovative heart support technology that safely assists both sides of the heart, aiming to improve treatment accessibility and cost-effectiveness for end-stage heart failure patients.
Transcatheter Ventricular Repair Device for treatment of Heart Failure Patients
Cardiac Success aims to develop the V-sling, a transcatheter device to enhance heart function in heart failure patients, through product optimization and pre-clinical testing.
TowArd demoCRatization Of ev-BAsed Therapies
EVerZom aims to revolutionize EV manufacturing with a patented scalable process, targeting GMP compliance and commercial production to lead the European market in clinical applications.
Recombinant fibrinogen for extravascular support (EVS) after vein bypass grafting
Fibriant BV ontwikkelt een kosteneffectieve, recombinant fibrinogeenvariant voor extravasculaire steun bij bypass chirurgie om afsluiting van getransplanteerde aderen te verminderen.
Prefabricated Mature Blood Vessels and Tools for Vascularized 3D Cell Culture
The Vasc-on-Demand project aims to develop three innovative products for easy generation of vascularized 3D tissues, enhancing research and drug testing while reducing reliance on animal trials.