SubsidieMeestersNanoengineered photoactivated drug-free antimicrobial precision treatment for chronic skin wounds
This project aims to validate a drug-free PHOTOCURE wound patch that uses photocatalytic activity to effectively eradicate antibiotic-resistant biofilms in chronic skin infections like diabetic foot ulcers.
Projectdetails
Introduction
Antibiotic-resistant bacterial skin and soft tissue infections (SSTIs) are difficult to diagnose and treat, prolonging hospital stays and lowering quality of life. Chronic wounds harbour antibiotic-resistant microorganisms that form biofilms, leading to conditions like diabetic foot ulcers (DFUs).
Prevalence and Impact
Approximately 50% of DFUs become infected, making them the most prevalent and costly diabetes complication, with a higher mortality and morbidity risk from lower limb amputation. There is an urgent need to develop effective, localised solutions for treating SSTIs that do not depend on antibiotics, especially against complex biofilms like those occurring in DFU cases.
Project Overview
In this Proof of Concept project, we will evaluate a PHOTOCURE wound patch: a porous nanothin Ag/TiOx film with visible-light photocatalytic activity that produces superoxide radicals to effectively eradicate biofilms in the SSTIs context.
Features of the PHOTOCURE Patch
- Enhanced mechanical stability for durability
- Sustained activity across multiple irradiation cycles
- A viable option for recurrent treatment
The PHOTOCURE patch presents a more efficient drug-free alternative to conventional antibiotic treatments, with reduced adverse effects, addressing the escalating challenges of antibiotic and multidrug resistance.
Validation and Strategy
The project will validate the antimicrobial efficacy of TiOx-polymer nanocomposite patches against both single and multiple-species biofilms relevant to chronic SSTIs, notably DFUs, using ex vivo and in vivo human-relevant models.
Intellectual Property and Market Analysis
Subsequently, we will devise a comprehensive IP strategy, secure initial patents, and conduct thorough market and competitor analyses within the antimicrobial wound care dressing sector.
Business Case Development
Finally, we will outline a detailed business case for advancing the PHOTOCURE prototype to market.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-10-2024 |
| Einddatum | 31-3-2026 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- KAROLINSKA INSTITUTETpenvoerder
- AETHERPHLOX AB
Land(en)
Vergelijkbare projecten binnen European Research Council
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|---|---|---|---|---|
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Personalised Bioelectronics for Epithelial Repair
ProBER aims to develop personalized bioelectronic wound dressings using conformal DC electrodes to enhance healing speed and efficiency in chronic wounds, preparing for clinical studies.
SAFE-ON Technology for Smart Antimicrobial Coatings
This project aims to optimize and commercialize the SAFE-ON antimicrobial coating technology through prototype development and market analysis to combat infectious diseases.
Modification of liposomic nano-carriers: a novel strategy for improved drug-delivery and eradication of bacterial biofilms
This project aims to develop and evaluate a novel drug delivery system to effectively treat and eradicate bacterial biofilms, addressing significant health and economic challenges.
Bioactive Tissue Sealant for Enhanced Wound Repair
BioTisSeal aims to create bioactive tissue sealants using gelatin methacryloyl and aptamers for enhanced wound healing and market readiness, addressing current limitations in wound care.
Overcoming limits for pre-clinical small volume liquid delivery into skin and inflammation quantification
This project aims to validate the BuBble Gun injection method using Skin-On-Chip technology for localized drug testing in chronic skin diseases, paving the way for innovative treatment delivery.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
A Paradigm Shift in Health Monitoring with Electrospun Enzymatic NeomaterialsWOUNDSENS aims to develop innovative wearable biosensors integrated into smart wound dressings to enhance chronic wound monitoring and improve patient quality of life. | EIC Pathfinder | € 2.934.318 | 2023 | Details |
Antibacterial wound dressing based on advanced nanotechnology to improve the efficiency of wound careNanordica aims to revolutionize wound care with an advanced antibacterial dressing that significantly reduces infections, lowers healthcare costs, and improves patient outcomes. | EIC Accelerator | € 2.402.750 | 2023 | Details |
A novel, first-in-its-kind, aptamer-based LYTACs to address the unmet clinical need of diabetic wounds.APTADEGRAD aims to demonstrate the efficacy of novel aptamer-based LYTACs in healing diabetic foot ulcers by targeting key inflammatory proteins to improve treatment outcomes. | EIC Pathfinder | € 2.321.677 | 2022 | Details |
iCap Fotobiomodulatie apparaatDit project valideert een innovatief biofotomodulatie apparaat voor de genezing van complexe wonden bij diabetes type 2 patiënten. | 1.1 - Het ve... | € 32.000 | 2024 | Details |
Targeted Nano-formulations for Treatment of MRSA: A multicomponent platform for nano-formulated treatment of resistant microbial infectionsLeadToTreat aims to develop targeted nano-formulations for treating MRSA infections by co-delivering novel low-drugability compounds and synergistic antibiotic combinations. | EIC Pathfinder | € 2.665.564 | 2022 | Details |
A Paradigm Shift in Health Monitoring with Electrospun Enzymatic Neomaterials
WOUNDSENS aims to develop innovative wearable biosensors integrated into smart wound dressings to enhance chronic wound monitoring and improve patient quality of life.
Antibacterial wound dressing based on advanced nanotechnology to improve the efficiency of wound care
Nanordica aims to revolutionize wound care with an advanced antibacterial dressing that significantly reduces infections, lowers healthcare costs, and improves patient outcomes.
A novel, first-in-its-kind, aptamer-based LYTACs to address the unmet clinical need of diabetic wounds.
APTADEGRAD aims to demonstrate the efficacy of novel aptamer-based LYTACs in healing diabetic foot ulcers by targeting key inflammatory proteins to improve treatment outcomes.
iCap Fotobiomodulatie apparaat
Dit project valideert een innovatief biofotomodulatie apparaat voor de genezing van complexe wonden bij diabetes type 2 patiënten.
Targeted Nano-formulations for Treatment of MRSA: A multicomponent platform for nano-formulated treatment of resistant microbial infections
LeadToTreat aims to develop targeted nano-formulations for treating MRSA infections by co-delivering novel low-drugability compounds and synergistic antibiotic combinations.