MUlti-spectral Scattering matrix for Enhanced skin imaging

Introduction

During the ERC REMINISCENCE project, we developed a new microscope whose performances exceed our initial expectations. Based on a reflection matrix approach of wave imaging, this device called DeepInsight provides an unprecedented imaging performance.

Imaging Capabilities

It allows non-invasive, label-free, real-time, and three-dimensional imaging of tissues with a 1 mm penetration depth at a 500 nm resolution.

Quantitative Imaging

Beyond the structural information provided by standard reflectivity images, it also enables quantitative imaging of tissues by mapping biomarkers such as:

• The refractive index
• Tissue dynamics
• Scattering strength

This patented innovation thus represents a paradigm shift in label-free microscopy.

Applications in Dermatology and Cosmetics

In the framework of this project, we want to investigate its extremely promising potential for the dermatology and cosmetics industry. Our proposed solution overcomes the fundamental limitations of existing microscopes (confocal / OCT) in terms of:

1. Penetration depth
2. Resolution
3. 3D frame rate

Early Detection of Melanoma

It will be a turning point for the early detection of melanoma, which remains a blind spot for current technologies.

Non-Invasive Angiography

Beyond this specific problem, its real-time capabilities will be exploited for non-invasive angiography in order to identify subsurface vascular and structural features known to be associated with numerous skin diseases.

Future Plans

Following the PoC project, we plan to establish a start-up company to further develop the microscope and market it to hospitals and the cosmetics industry.