Bispecific bi-paratopic antibodies for the treatment of cancer

Introduction

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the majority of patients do not respond to current treatments, such as PD-1/PD-L1 blockade. In non-small cell lung cancer (NSCLC), over 70% of patients experience immune evasion mechanisms that prevent effective immune activation.

Mechanisms of Immune Evasion

One such mechanism involves the overexpression of glycans on tumor cells, which can modulate immune responses.

Project Proposal

In this project, we propose to develop novel bispecific bi-paratopic antibodies that simultaneously target two distinct epitopes of the target. This innovative approach is designed to provide a more comprehensive blockade of immune-suppressive functions by dual engagement of the receptor.

Engineering and Optimization

Our bispecific antibodies will be engineered and optimized to target different epitopes, enhancing their ability to restore immune function. The project will involve:

1. Engineering of the bispecific antibodies
2. Structural characterization
3. Functional validation of the antibodies
4. Preclinical efficacy studies in NSCLC models

Potential Impact

By this approach, these antibodies have the potential to overcome the limitations of existing immunotherapies, offering a new therapeutic option for cancer patients who are resistant to current treatments.

Commercialization Strategy

In addition to the scientific development, this ERC PoC project is designed to develop a robust commercialization strategy, with the potential for patent filings and engagement with pharmaceutical partners.

Vision

Our vision is to bring these bispecific antibodies to the clinic, ultimately aiming to improve outcomes for patients with NSCLC and other cancers.