Vesicular mechanisms of carbon fixation in calcifying cells of marine animals
CarboCell aims to uncover the mechanisms of vesicular calcification in sea urchin larvae to enhance understanding of CO2 transformation and its implications for marine biology and carbon capture solutions.
Projectdetails
Introduction
The process of biomineralization has profound impacts on the geology of our planet and is an integral part of the global carbon cycle by generating large amounts of CaCO3 bound in coral reefs, chalk mountains, and deep-sea sediments. Mounting evidence demonstrates that many marine calcifiers generate biominerals by the intracellular formation of CaCO3 from seawater Ca2+ and metabolic CO2.
Research Gaps
To date, the underlying mechanisms that control the carbonate chemistry in calcifying vesicles are unknown. Understanding these mechanisms will provide groundbreaking insights into a biological process that is capable of transforming a metabolic waste product - CO2 - into a versatile construction material.
Methodological Expertise
In the past 5 years, my group has developed a unique methodological expertise to study the cellular physiology of calcifying systems. Building on this expertise, CarboCell will tackle the important but challenging task of identifying and understanding the mechanisms of vesicular calcification.
Model Organism
The sea urchin larva will serve as a powerful model organism, representing a prime example for the intracellular formation of CaCO3. This model allows us to employ specifically targeted molecular perturbations in combination with sub-cellular ion and pH recordings.
Research Strategy
CarboCell will take a stepwise strategy to systematically examine the mechanisms of vesicular calcification on three main core subjects:
- Carbonate chemistry (WP1)
- Ion/CO2 transport mechanisms (WP2)
- Vesicular volume regulation and trafficking (WP3)
Implications
CarboCell will provide a deep mechanistic understanding of the calcification process, with strong implications for explaining and predicting responses of marine calcifiers to the global phenomenon of ocean acidification.
Future Directions
More importantly, knowledge about the mechanisms that allow organisms to transform CO2 into a construction material will pave the ground for novel, biology-inspired solutions of CO2 capture and utilization – a basic science approach at the core of twenty-first-century concerns.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 2.000.000 |
Totale projectbegroting | € 2.000.000 |
Tijdlijn
Startdatum | 1-7-2023 |
Einddatum | 30-6-2028 |
Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIELpenvoerder
Land(en)
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