SubsidieMeestersBrain fluids - Transport and clearance
The "aCleanBrain" project aims to uncover brain fluid dynamics mechanisms and develop advanced simulation algorithms using machine learning for better understanding of neurodegenerative diseases.
Projectdetails
Introduction
Scientific breakthroughs in neuroscience explain the need for sleep and the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases in terms of fluid dynamics: the waste created during the day is cleared away as we sleep or it accumulates.
Research Background
However, a decade of research after the original theory was posed has revealed that the underlying physical mechanisms are still not understood and that advanced mathematical tools are needed.
Project Proposal
In this project, we propose a research program addressing:
- New fluid dynamics mechanisms
- Novel numerical analysis for advanced multi-physics brain simulations
- A framework for patient-specific simulations
We will exploit reduced order and machine learning methods in addition to finite element solutions.
Expected Outcomes
With successful delivery, the "aCleanBrain" will:
- Establish the main drivers of brain fluid dynamics
- Provide a foundation for accurate, efficient, and robust algorithms for multi-physics problems
- Develop a software framework for advanced biomechanical brain simulations
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.493.750 |
| Totale projectbegroting | € 2.493.750 |
Tijdlijn
| Startdatum | 1-8-2024 |
| Einddatum | 31-7-2029 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- SIMULA RESEARCH LABORATORY ASpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
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|---|---|---|---|---|
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Bidirectional Brain/Neural-Computer Interaction for Restoration of Mental HealthThis project aims to develop a portable neuromodulation system using quantum sensors and magnetic stimulation to precisely target brain oscillations for treating mental health disorders. | ERC Consolid... | € 1.999.875 | 2025 | Details |
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4D Brain-Targeting Nanomedicines for Treating Neurodegeneration
This project aims to develop advanced 4D-brain-targeting nanoparticles using nanotechnology to effectively deliver treatments for neurodegenerative diseases across the blood-brain barrier.
Map and manipulate sleep oscillations to reveal their role in healthy cognitive development
This project aims to investigate the causal relationship between sleep architecture and cognitive development in young mammals using advanced neurobiological techniques to inform therapeutic strategies for developmental disorders.
The Silent Phase of Alzheimer’s Disease: From Brain States to Homeostatic Failures
This project aims to uncover the mechanisms stabilizing hippocampal circuits and their relation to Alzheimer's disease by exploring homeostatic regulation across brain states using diverse experimental tools.
Bidirectional Brain/Neural-Computer Interaction for Restoration of Mental Health
This project aims to develop a portable neuromodulation system using quantum sensors and magnetic stimulation to precisely target brain oscillations for treating mental health disorders.
Drug DELIvery to the brain via CHOroid Plexus targeting
This project aims to explore the blood-CSF barrier as a novel route for delivering therapeutics to the brain, potentially enhancing treatment strategies for CNS disorders.
Vergelijkbare projecten uit andere regelingen
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|---|---|---|---|---|
Remote whole-brain functional microscopy of the vascular system: a paradigm shift for the monitoring and treatment of small vessel diseasesThe project aims to revolutionize neuroimaging by developing functional Ultrasound Localization Microscopy (fULM) for high-resolution monitoring of brain vasculature and function, enhancing disease diagnosis and treatment evaluation. | EIC Pathfinder | € 3.946.172 | 2022 | Details |
twiN-on-a-chip brAins for monitoring individual sleeP habitsNAP aims to revolutionize sleep research by developing personalized in vitro models to identify sleep disorders and early Parkinson's Disease signs, enhancing diagnostics and reducing healthcare costs. | EIC Pathfinder | € 3.615.375 | 2023 | Details |
Opto-Electronic Neural Connectoid Model Implemented for Neurodegenerative DiseaseThe project aims to develop a novel human brain-organoid model, called connectoids, to replace animal testing for Parkinson's disease, enhancing therapy monitoring and reducing societal burdens. | EIC Pathfinder | € 2.992.203 | 2022 | Details |
Distributed and federated cross-modality actuation through advanced nanomaterials and neuromorphic learningCROSSBRAIN aims to revolutionize brain condition treatment using implantable microbots for real-time, adaptive neuromodulation and sensing in rodent models of Parkinson's Disease and Epilepsy. | EIC Pathfinder | € 4.034.074 | 2022 | Details |
Humane mini-breinen voor R&D-toepassingenHet project ontwikkelt een applicatie voor het kweken en analyseren van humane mini-breinen, ter vermindering van dierproeven. | Mkb-innovati... | € 744.000 | 2021 | Details |
Remote whole-brain functional microscopy of the vascular system: a paradigm shift for the monitoring and treatment of small vessel diseases
The project aims to revolutionize neuroimaging by developing functional Ultrasound Localization Microscopy (fULM) for high-resolution monitoring of brain vasculature and function, enhancing disease diagnosis and treatment evaluation.
twiN-on-a-chip brAins for monitoring individual sleeP habits
NAP aims to revolutionize sleep research by developing personalized in vitro models to identify sleep disorders and early Parkinson's Disease signs, enhancing diagnostics and reducing healthcare costs.
Opto-Electronic Neural Connectoid Model Implemented for Neurodegenerative Disease
The project aims to develop a novel human brain-organoid model, called connectoids, to replace animal testing for Parkinson's disease, enhancing therapy monitoring and reducing societal burdens.
Distributed and federated cross-modality actuation through advanced nanomaterials and neuromorphic learning
CROSSBRAIN aims to revolutionize brain condition treatment using implantable microbots for real-time, adaptive neuromodulation and sensing in rodent models of Parkinson's Disease and Epilepsy.
Humane mini-breinen voor R&D-toepassingen
Het project ontwikkelt een applicatie voor het kweken en analyseren van humane mini-breinen, ter vermindering van dierproeven.