A disruptive hypoxia activated prodrug for the treatment of resistant cancers: an AI-driven approach

TUMAGOSTIC aims to advance CP-506, a targeted Hypoxia Activated Prodrug, through clinical trials to improve cancer treatment efficacy and patient outcomes, with commercialization potential exceeding €450M.

Subsidie
€ 2.462.533
2024

Projectdetails

Introduction

TUMAGOSTIC will advance the development of CP-506, a next-generation Hypoxia Activated Prodrug (HAP) for the treatment of hypoxic tumours, representing over 50% of all solid tumours.

Advantages of CP-506

CP-506 overcomes the limitations of previous HAP development attempts and can provide more targeted treatment compared with alternatives such as:

  • Chemo-immunotherapy combination
  • PARPi

Innovative Approach

Our approach, combining CP-506 with improved patient targeting based on two AI-driven biomarkers (tumour hypoxia and Homologous Recombination Defect), has high potential to increase the effectiveness of standard of care therapies such as immunotherapy (IO) in combination therapy (prodrug-IO).

Expected Outcomes

This innovative strategy aims to improve patients’ progression-free survival and quality of life in several cancer types.

Commercialization Plans

We aim to advance CP-506 towards commercialization by carrying out a phase I-IIa clinical trial and corresponding business development activities, paving the way for a licensing agreement with the potential to exceed €450M.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 2.462.533
Totale projectbegroting€ 3.517.905

Tijdlijn

Startdatum1-1-2024
Einddatum31-12-2025
Subsidiejaar2024

Partners & Locaties

Projectpartners

  • CONVERT PHARMACEUTICALSpenvoerder

Land(en)

Belgium

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