SubsidieMeestersProtein-RNA interaction stabilization using molecular glues
This project aims to develop PRIGLUEs to stabilize RNA-protein interactions, enhancing mRNA splicing and potentially leading to novel therapeutic tools for RNA biology.
Projectdetails
Introduction
Protein-RNA interactions play a key role in cell biology and there are limited tools for specific modulation. In this project, we will look for molecules that act as glues by stabilizing the interaction between an RNA-binding protein and a specific RNA sequence, which we call PRIGLUEs.
Project Aims
The aims are to:
- Explore key concepts of how to develop screening methods to identify such PRIGLUEs.
- Determine what type of chemical matter is suitable for this approach.
Evaluation of Molecular Glues
These novel molecular glues will be evaluated for their RNA selectivity and the mode of interaction stabilization. The methods we will develop to identify PRIGLUEs can be applied to any protein-RNA interaction.
Application in mRNA Splicing
We will use these methods to modulate the process of mRNA splicing to prove the concept. The glues will be applied to stabilize mutant splicing factor – RNA pairs to recover lost affinity and correct disease-causing splicing outcomes.
Future Implications
PRIGLUEs will be applicable as novel tools for RNA biology studies but can eventually also lead to therapeutics with an unexplored mode of action.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.500.000 |
| Totale projectbegroting | € 1.500.000 |
Tijdlijn
| Startdatum | 1-6-2023 |
| Einddatum | 31-5-2028 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EVpenvoerder
Land(en)
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This project aims to develop RNAylated proteins as innovative RNA therapeutics by establishing design principles and delivery strategies to regulate cellular processes, including targeting the p53 protein.
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