K-edge imaging for cOLOR Spectral Photon-Counting Computed Tomography in lung diseases IMAGING

Introduction

Computed tomography (CT) is the mainstay of lung imaging because of its higher spatial resolution, convenience, availability, and faster time of acquisition in comparison with other imaging methods such as magnetic resonance imaging (MRI) and nuclear imaging. However, CT’s lack of specificity and absolute quantitative capabilities limits the comprehensive guidance of therapeutic strategies based on imaging assessment of oncologic, inflammatory, and fibrotic pathophysiology processes.

Emerging Technology

Spectral photon-counting CT is an emerging CT technology that not only capitalizes on all CT’s advantages but also offers a cutting-edge method of imaging, called Color K-edge imaging. This method allows the specific and quantitative identification of one or multiple atoms concomitantly within a tissue, enabling the simultaneous imaging of independent or interacting pathways.

Limitations

However, K-edge imaging is still limited by its low sensitivity and the scarce availability of contrast agents for potential human translation, and therefore has not been translated yet to practice. Addressing these issues would be extremely beneficial to the diagnostic and theragnostic evaluation of lung diseases in general and more specifically, lung fibrosis and cancer.

Project Goals

Therefore, the goal of this proposal is to develop a framework of SPCCT Color K-edge imaging to provide high-resolution specific and quantitative imaging for non-targeting and targeting agents’ candidates, mainly from the nanobiotechnology field.

Methodology

We will carry out preclinical studies to evaluate the contribution in combination with the contrast agents using different routes of injection, either by:

1. Intravenous injection
2. Inhalation

This will open the possibility for the concomitant imaging of lung ventilation and perfusion for monitoring the inflammation and pulmonary agent delivery in animal models.