SubsidieMeestersCorrecting for self: The impact of head motion on visual processing and behaviour.
This project aims to uncover the neuronal circuits connecting the vestibular system to visual processing in mice, enhancing understanding of sensory integration during self-motion.
Projectdetails
Introduction
An organism’s survival depends on accurately perceiving and interpreting the environment. A significant part of our visual stimuli is, however, generated by our own actions, rather than external events. For example, the retina can experience similar visual stimuli driven by head movement or by a moving object.
Importance of Self-Motion Information
Therefore, self-motion related information is fundamental to contextualize visual stimuli. In other words, what the eye sees may not be what our brain perceives depending on our actions.
The Vestibular System
In mammals, the vestibular system reports both the motion and orientation of the head. Very little is known about the pathways connecting the vestibular system to visual cortical areas, and how this signal is integrated with external visual stimuli to ultimately impact behaviour.
Project Goals
The goal of this project is to unravel the neuronal circuits underlying visual processing during self-motion in mice, thereby providing new insights into sensory processing. To this aim, I will address the following questions:
- What is the long-range and local connectivity of neurons modulated by head rotation in V1?
- What are the circuit mechanisms and neuronal computations involved in the integration of self-motion related signals with visual inputs in V1?
- How do head motion inputs to V1 influence visually-guided actions during behaviour?
Methodology
Achieving these goals relies on a multidisciplinary experimental strategy based on cutting-edge approaches to monitor and control circuit activity with high spatio-temporal resolution in a cell-type specific manner, neuroanatomical tracing, and computational modelling.
Research Background
This experimental strategy, combined with my research background in visual and vestibular systems, provides a unique opportunity to understand unexplored aspects of sensory processing, at both the cellular and systems levels.
Conclusion
Altogether, this project will reveal a novel framework to understand how sensory processing operates during self-motion to guide behaviour.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.499.639 |
| Totale projectbegroting | € 1.499.639 |
Tijdlijn
| Startdatum | 1-1-2024 |
| Einddatum | 31-12-2028 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRSpenvoerder
Land(en)
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This project aims to investigate how the superior colliculus integrates retinal signals to drive behavior using imaging, optogenetics, and modeling, revealing mechanisms of visual information processing.
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This project aims to investigate the circuit and neuromodulatory mechanisms of sensory prediction learning in the visual cortex, enhancing understanding of self-generated feedback processing and its implications for neurodevelopmental conditions and AI.
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This project aims to investigate the neural circuits in Drosophila that monitor and correct movement errors, linking neural activity to behavioral outcomes in walking control.
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AdaptiveVision aims to uncover common principles of visual systems by studying contrast estimation and motion encoding in Drosophila, linking molecular mechanisms to behavioral adaptations across diverse environments.
Untangling population representations of objects. A closed loop approach to link neural activity to mouse behavior.
This project aims to develop a virtual navigation system for mice to study how visual representations in the brain influence behavior, enhancing our understanding of object recognition in natural environments.