SubsidieMeestersTargeted Respiratory Drug Delivery by Tribo Charged Sprays
Develop a new technology for precise drug delivery to the lungs using charged droplets to prevent coalescence, enhancing treatment efficacy for conditions like lung cancer and COVID-19.
Projectdetails
Introduction
The main purpose of this proposal is to develop a radically new technology for very precisely delivering medicine to the human body. Targeted deposition of drug formulations to the lungs exhibits great promise in several treatments, e.g. siRNA treatment against lung cancer or mRNA vaccination against COVID-19.
Current Challenges
This requires oral and nasal inhalation for which spray pumps and nebulizers are widely used to transform an aqueous formulation into a soft mist spray. However, producing the necessary drop size is hampered by droplet coalescence, making drops too large and polydisperse; because of this, they deposit in the wrong places.
- Large droplets between 10 and 50 micrometers deposit mostly in the upper respiratory tract (mouth, throat, or nasal cavity) through ballistic impact on the mucosal tissue.
- Small droplets between 5 and 10 micrometers can be lifted by the airstreams and deposit mostly in the lower respiratory tract (bronchi and lungs).
Proposed Innovation
Our innovation relies on the charging of drops through the friction with the nozzle material. The charged drops repel and do not coalesce, allowing precise control of their size to target, e.g., the lungs.
Conclusion
This allows us to achieve safe and effective targeted deposition of drugs and/or vaccines with hitherto unequaled precision.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-1-2024 |
| Einddatum | 30-6-2025 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSITEIT VAN AMSTERDAMpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Focused Targeting of Inhaled Magnetic Aerosols for Lung CancerAEROTARG aims to enhance targeted delivery of inhaled chemotherapeutics to lung tumors using magnetically-loaded aerosols and a custom magnetic field, improving efficacy and reducing side effects. | ERC Proof of... | € 150.000 | 2023 | Details |
Dry Powder Formulation of RNA Nanoparticles for Inhalation and Improved Storage and Transport ConditionsRNhale aims to develop a platform technology for spray-drying RNA nanoparticles to enhance stability and target delivery, ultimately seeking licensing agreements with pharmaceutical companies. | ERC Proof of... | € 150.000 | 2022 | Details |
Precision Rayleigh jet spraysThis project aims to develop novel spray nozzles that produce perfectly monodisperse sprays by controlling instabilities through advanced hydrodynamics and nanofabrication, enhancing applications in medicine and agriculture. | ERC Advanced... | € 2.500.000 | 2025 | Details |
Rational and Simulation-Supported Design of Inhalable RNA NanocarrierRatInhalRNA aims to design and optimize biocompatible siRNA nanoparticles for pulmonary delivery using a combination of DoE, MD simulations, and ML to enhance gene silencing efficacy. | ERC Consolid... | € 2.000.000 | 2023 | Details |
Skin micro-injectorBold-Jet aims to revolutionize needle-free injections with a microjet device that enhances safety, minimizes invasiveness, and improves patient adherence to treatments. | ERC Proof of... | € 150.000 | 2022 | Details |
Focused Targeting of Inhaled Magnetic Aerosols for Lung Cancer
AEROTARG aims to enhance targeted delivery of inhaled chemotherapeutics to lung tumors using magnetically-loaded aerosols and a custom magnetic field, improving efficacy and reducing side effects.
Dry Powder Formulation of RNA Nanoparticles for Inhalation and Improved Storage and Transport Conditions
RNhale aims to develop a platform technology for spray-drying RNA nanoparticles to enhance stability and target delivery, ultimately seeking licensing agreements with pharmaceutical companies.
Precision Rayleigh jet sprays
This project aims to develop novel spray nozzles that produce perfectly monodisperse sprays by controlling instabilities through advanced hydrodynamics and nanofabrication, enhancing applications in medicine and agriculture.
Rational and Simulation-Supported Design of Inhalable RNA Nanocarrier
RatInhalRNA aims to design and optimize biocompatible siRNA nanoparticles for pulmonary delivery using a combination of DoE, MD simulations, and ML to enhance gene silencing efficacy.
Skin micro-injector
Bold-Jet aims to revolutionize needle-free injections with a microjet device that enhances safety, minimizes invasiveness, and improves patient adherence to treatments.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Onderzoek naar het toedienen van antivirale formuleringen middels spray nozzletechnologie geïntegreerd in een neusspray ter preventie van respiratoire infectiesHet project onderzoekt de technische en economische haalbaarheid van een short fatty acid-neusspray als antivirale bescherming met optimale verneveling en kostprijsanalyse. | Mkb-innovati... | € 20.000 | 2023 | Details |
FIBAIR - Inhalation spray nozzles with improved air mixing for lung fibrosisHet project ontwikkelt nieuwe mixkamer-technologie voor inhalatoren om de behandeling van longfibrose bij (ex-)COVID-19-patiënten te verbeteren en de levensverwachting te verhogen. | Mkb-innovati... | € 270.891 | 2020 | Details |
Just BreatheGilbert en Unitron ontwikkelen een soft mist-inhaler om medicatie voor longaandoeningen effectiever en aangenamer te maken. | 1.1 - Het ve... | € 322.278 | 2024 | Details |
VernevelaarEnceladus Pharmaceuticals onderzoekt liposomale ontstekingsremmers voor gebruik in een geavanceerde electrospray-vernevelaar om medicatie effectief in de longblaasjes af te leveren. | Mkb-innovati... | € 20.000 | 2022 | Details |
ARISE - Advanced RNA Inhalation Solutions anchored in Evolved dry powder technology.RNhale's project aims to revolutionize RNA therapeutics for pulmonary diseases by developing inhalable dry powder formulations of RNA encapsulated in lipid nanoparticles. | EIC Transition | € 2.421.498 | 2025 | Details |
Onderzoek naar het toedienen van antivirale formuleringen middels spray nozzletechnologie geïntegreerd in een neusspray ter preventie van respiratoire infecties
Het project onderzoekt de technische en economische haalbaarheid van een short fatty acid-neusspray als antivirale bescherming met optimale verneveling en kostprijsanalyse.
FIBAIR - Inhalation spray nozzles with improved air mixing for lung fibrosis
Het project ontwikkelt nieuwe mixkamer-technologie voor inhalatoren om de behandeling van longfibrose bij (ex-)COVID-19-patiënten te verbeteren en de levensverwachting te verhogen.
Just Breathe
Gilbert en Unitron ontwikkelen een soft mist-inhaler om medicatie voor longaandoeningen effectiever en aangenamer te maken.
Vernevelaar
Enceladus Pharmaceuticals onderzoekt liposomale ontstekingsremmers voor gebruik in een geavanceerde electrospray-vernevelaar om medicatie effectief in de longblaasjes af te leveren.
ARISE - Advanced RNA Inhalation Solutions anchored in Evolved dry powder technology.
RNhale's project aims to revolutionize RNA therapeutics for pulmonary diseases by developing inhalable dry powder formulations of RNA encapsulated in lipid nanoparticles.