SubsidieMeestersMetaraminol Demonstration Plant as Commercialisation Blueprint for Sustainable Production of Pharmaceuticals using Enzyme Cascades
'SusECAS - DemoPlant' aims to establish a sustainable, biocatalytic process for producing amino alcohols in Europe, enhancing ecological and economic viability while facilitating market entry.
Projectdetails
Introduction
The development of more environmentally friendly synthesis methods is urgently needed if humanity wants to maintain an environment worth living in. The establishment of more biocatalytic steps in chemical synthesis is a possible solution, as enzymes and whole cells offer sustainable advantages such as biodegradability, toxicity, high selectivity, and much more.
Valuable Compounds
Amino alcohols and 2-hydroxy ketones are valuable compounds with various applications in the chemical and pharmaceutical industry, with market prices >1000 €/kg, but challenging synthesis strategies. As a result of synthesis options with disastrous footprints, these molecules are often produced in countries with poor working conditions and significantly lower safety and environmental standards than those accepted in the EU.
Project Overview
The idea of 'SusECAS - DemoPlant' is simple. An innovative economic and ecological competitive process will enable a sustainable production of amino alcohols in Europe. In the ERC Starting Grant project 'LightCas', Prof. Rother laid the base with an atomic and step-efficient enzymatic 2-step reaction for amino alcohols from inexpensive starting materials (<10-100 €/kg).
Industrial Application
In 'SusECAS', we will take these innovative synthesis ideas to a new level of industrial application. A multi-gram demonstration plant will enable model-based process evaluation, giving us and our customers clear indications of the ecological and economic potential.
Market Analysis
A systematic market analysis will provide an overview of the competitive structure of the overall market, the market volume, and the requirements of potential customers. Supported by business angels, commercialization strategies will be evaluated.
Business Development
In 'SusECAS', we will develop a business plan for commercialization and initiate a step-by-step market introduction of our products and technologies.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-10-2022 |
| Einddatum | 31-3-2024 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- FORSCHUNGSZENTRUM JULICH GMBHpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Commercial feasibility of a cell-free reactor setup for optimisation of complex enzymatic pathwaysThis project aims to commercialize a continuous stirred tank reactor for optimizing complex enzymatic pathways, enhancing production efficiency and establishing a viable commercialization strategy. | ERC Proof of... | € 150.000 | 2022 | Details |
Translating a new metabolic engineering strategy to industrial biotech applicationsThe TRANSMETECH project aims to translate the StrainBooster metabolic engineering strategy into industrial applications, enhancing bioprocess efficiency for sustainable chemical production. | ERC Proof of... | € 150.000 | 2023 | Details |
Development of rationally designed enzyme kitsKITZYME aims to create patentable enzyme kits for stereoselective carbon-carbon bond formation using advanced computational methods to enhance catalytic efficiency sustainably and cost-effectively. | ERC Proof of... | € 150.000 | 2024 | Details |
Enzymatic chemistry acting on alkyl chainsThe project aims to discover and characterize novel biocatalysts from cyanobacteria to enable selective functionalization of alkyl chains for sustainable production of organic chemicals. | ERC Consolid... | € 1.995.621 | 2024 | Details |
Advanced Molecular ENantiodiscriminationThe AMEN project aims to develop scalable chiral microreactor technology for the selective production of pharmaceutical enantiomers, ensuring safety and efficacy in drug formulations. | ERC Proof of... | € 150.000 | 2024 | Details |
Commercial feasibility of a cell-free reactor setup for optimisation of complex enzymatic pathways
This project aims to commercialize a continuous stirred tank reactor for optimizing complex enzymatic pathways, enhancing production efficiency and establishing a viable commercialization strategy.
Translating a new metabolic engineering strategy to industrial biotech applications
The TRANSMETECH project aims to translate the StrainBooster metabolic engineering strategy into industrial applications, enhancing bioprocess efficiency for sustainable chemical production.
Development of rationally designed enzyme kits
KITZYME aims to create patentable enzyme kits for stereoselective carbon-carbon bond formation using advanced computational methods to enhance catalytic efficiency sustainably and cost-effectively.
Enzymatic chemistry acting on alkyl chains
The project aims to discover and characterize novel biocatalysts from cyanobacteria to enable selective functionalization of alkyl chains for sustainable production of organic chemicals.
Advanced Molecular ENantiodiscrimination
The AMEN project aims to develop scalable chiral microreactor technology for the selective production of pharmaceutical enantiomers, ensuring safety and efficacy in drug formulations.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
TUNGSTEN BIOCATALYSIS – HEAVY METAL ENZYMES FOR SUSTAINABLE INDUSTRIAL BIOCATALYSISThis project aims to develop a new W-cofactor biosynthesis pathway in E. coli to produce tungsten-containing enzymes for sustainable chemical processes, enabling efficient CO2 reduction and cosmetic ingredient production. | EIC Pathfinder | € 2.430.574 | 2024 | Details |
Closing Carbon Cycles with Renewable Amines (3CRA)Het project richt zich op de duurzame synthese van amines uit biomassa en end-of-life plastics, met als doel CO2-reductie en het sluiten van koolstofcycli voor polyamiden en polyurethanes. | Missiegedrev... | € 3.193.418 | 2023 | Details |
Biosensor Activated Biomanufacturing Scale-upEnduro aims to revolutionize microbial biomanufacturing with its synthetic biology plugin, Enduro Sense, to enable scalable processes and attract investment for commercial deployment. | EIC Accelerator | € 1.815.295 | 2023 | Details |
Electrobiocatalytic cascade for bulk reduction of CO2 to CO coupled to fermentative production of high value diamine monomersECOMO aims to innovate sustainable production of high-value diamines from CO2 and nitrogen using bioelectrocatalysis and engineered microbes, enhancing chemical industry building blocks. | EIC Pathfinder | € 3.776.701 | 2023 | Details |
Cascades for Stereoselective Synthesis of Amino AcidscassaFLOW aims to develop a 3-step biocatalytic synthesis of non-natural isoleucine, streamlining production for pharmaceuticals like Paxlovid and enhancing EU strategic autonomy. | EIC Transition | € 2.378.694 | 2024 | Details |
TUNGSTEN BIOCATALYSIS – HEAVY METAL ENZYMES FOR SUSTAINABLE INDUSTRIAL BIOCATALYSIS
This project aims to develop a new W-cofactor biosynthesis pathway in E. coli to produce tungsten-containing enzymes for sustainable chemical processes, enabling efficient CO2 reduction and cosmetic ingredient production.
Closing Carbon Cycles with Renewable Amines (3CRA)
Het project richt zich op de duurzame synthese van amines uit biomassa en end-of-life plastics, met als doel CO2-reductie en het sluiten van koolstofcycli voor polyamiden en polyurethanes.
Biosensor Activated Biomanufacturing Scale-up
Enduro aims to revolutionize microbial biomanufacturing with its synthetic biology plugin, Enduro Sense, to enable scalable processes and attract investment for commercial deployment.
Electrobiocatalytic cascade for bulk reduction of CO2 to CO coupled to fermentative production of high value diamine monomers
ECOMO aims to innovate sustainable production of high-value diamines from CO2 and nitrogen using bioelectrocatalysis and engineered microbes, enhancing chemical industry building blocks.
Cascades for Stereoselective Synthesis of Amino Acids
cassaFLOW aims to develop a 3-step biocatalytic synthesis of non-natural isoleucine, streamlining production for pharmaceuticals like Paxlovid and enhancing EU strategic autonomy.