SubsidieMeestersHigh-throughput production of anisotropic 3D human tissue models
Developing a magnetic hydrogel system to create 3D tissue models that accurately mimic human tissue architecture, enhancing drug discovery and personalized medicine efficiency.
Projectdetails
Introduction
The limitations of current in vitro tissue models pose a significant challenge in drug discovery and personalized medicine, leading to inefficiencies and unreliability in preclinical testing. These shortcomings result in high costs and prolonged timelines for drug development, straining resources and delaying patient access to innovative treatments.
Challenges of Current Models
This is mainly due to the currently available cell and tissue models based on flat petri dishes and isotropic hydrogels, which fail to accurately represent the anisotropic structures found in native tissues, leading to unreliable preclinical results.
Ethical Concerns with Animal Models
Animal models, although considered the gold standard, raise ethical concerns and introduce significant differences compared to human tissues.
Our Solution: Hydrogel System
To address these shortcomings, we have developed a hydrogel system that can be used to fabricate 3D culture models with oriented structures using AnisoPlate.
AnisoPlate Device
The AnisoPlate is a handheld magnetic device for providing the required external magnetic field in culture plates for the orientation of the rods.
Hydrogel Composition
The hydrogel system consists of rod-shaped elements that are made magneto-responsive by encapsulating superparamagnetic iron oxide nanoparticles (SPIONs).
Mechanism of Action
When exposed to low external magnetic fields (in the millitesla range) provided by the AnisoPlate, these rods align in the direction of the field and can be assembled into 3D macroporous oriented constructs mimicking the anisotropic architecture of human tissues.
Potential Impact
Our solution holds promise not only for researchers in drug discovery, tissue engineering, and regenerative medicine but also for:
- Pharmaceutical industries seeking physiologically relevant in vitro models for more accurate preclinical studies.
- Contract research organizations (CROs) aiming to enhance their efficacy in high-throughput screening.
- Ultimately, patients who stand to benefit from accelerated and improved drug development processes leading to innovative treatments.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-9-2024 |
| Einddatum | 28-2-2026 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EVpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Advanced 3D in vitro models based on magnetically-driven docking of modular microscaffoldsThis project aims to develop 3D modular co-culture systems using magnetic microscaffolds to replicate brain tumor microenvironments for drug screening and cancer therapy testing. | ERC Proof of... | € 150.000 | 2023 | Details |
High Throughput Modelling and Measurement of Human Epithelial Models using Electrospun Conducting Polymers For Unlocking Data-Driven Drug DiscoveryThe project aims to enhance drug discovery by developing simplified Organ on Chip platforms through hydrogel electrospinning, enabling scalable monitoring and integration into industry workflows. | ERC Proof of... | € 150.000 | 2025 | Details |
3D-assembly of interactive microgels to grow in vitro vascularized, structured, and beating human cardiac tissues in high-throughputHEARTBEAT aims to create personalized, vascularized millimeter-scale heart tissues using innovative microgel assemblies to enhance stem cell interactions and mimic native environments. | ERC Consolid... | € 2.969.219 | 2022 | Details |
Holographic Assembler for 3D Cell CulturesDevelop a user-friendly 3D bioassembler using acoustic holography for precise cell culture, enhancing drug screening relevance and commercialization potential. | ERC Proof of... | € 150.000 | 2023 | Details |
Engineering the Origin of Human Shape: Defining Patterns and Axes in the Early Stage of 3D PluripotencyOriSha aims to revolutionize in vitro human embryonic development modeling by using a hydrogel-microfluidic system to control biochemical signals for studying neural tube morphogenesis. | ERC Starting... | € 1.499.633 | 2024 | Details |
Advanced 3D in vitro models based on magnetically-driven docking of modular microscaffolds
This project aims to develop 3D modular co-culture systems using magnetic microscaffolds to replicate brain tumor microenvironments for drug screening and cancer therapy testing.
High Throughput Modelling and Measurement of Human Epithelial Models using Electrospun Conducting Polymers For Unlocking Data-Driven Drug Discovery
The project aims to enhance drug discovery by developing simplified Organ on Chip platforms through hydrogel electrospinning, enabling scalable monitoring and integration into industry workflows.
3D-assembly of interactive microgels to grow in vitro vascularized, structured, and beating human cardiac tissues in high-throughput
HEARTBEAT aims to create personalized, vascularized millimeter-scale heart tissues using innovative microgel assemblies to enhance stem cell interactions and mimic native environments.
Holographic Assembler for 3D Cell Cultures
Develop a user-friendly 3D bioassembler using acoustic holography for precise cell culture, enhancing drug screening relevance and commercialization potential.
Engineering the Origin of Human Shape: Defining Patterns and Axes in the Early Stage of 3D Pluripotency
OriSha aims to revolutionize in vitro human embryonic development modeling by using a hydrogel-microfluidic system to control biochemical signals for studying neural tube morphogenesis.
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|---|---|---|---|---|
Slim labinstrument voor 3D celculturenIMcoMET onderzoekt de ontwikkeling van een kosteneffectief labinstrument voor continue, niet-destructieve metingen van fysiologische parameters in 3D-celculturen voor geneesmiddelonderzoek. | Mkb-innovati... | € 20.000 | 2021 | Details |
Bringing 3D cardiac tissues to high throughput for drug discovery screensDeveloping a high-throughput 3D cardiac model using microfluidic technology to enhance drug discovery for cardiovascular disease by improving predictive accuracy and scalability. | EIC Transition | € 1.457.500 | 2023 | Details |
Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) Comprised of Live and Artificial Cells.Bio-HhOST aims to create bio-hybrid materials with living and artificial cells for dynamic communication, enhancing tissue modeling and reducing animal use in drug research. | EIC Pathfinder | € 1.225.468 | 2024 | Details |
High-throughput ultrasound-based volumetric 3D printing for tissue engineeringSONOCRAFT aims to revolutionize myocardial cell construct bioprinting by combining rapid volumetric printing with ultrasonic manipulation to create functional cardiac models for drug testing and disease research. | EIC Pathfinder | € 2.999.625 | 2025 | Details |
Dypha: adding the dimension of time to cell cultureThe δypha System aims to enhance drug development by providing a plug-and-play microfluidic adaptor for 96 well plates, enabling precise control of fluid kinetics in cell culture models. | EIC Transition | € 2.499.625 | 2024 | Details |
Slim labinstrument voor 3D celculturen
IMcoMET onderzoekt de ontwikkeling van een kosteneffectief labinstrument voor continue, niet-destructieve metingen van fysiologische parameters in 3D-celculturen voor geneesmiddelonderzoek.
Bringing 3D cardiac tissues to high throughput for drug discovery screens
Developing a high-throughput 3D cardiac model using microfluidic technology to enhance drug discovery for cardiovascular disease by improving predictive accuracy and scalability.
Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) Comprised of Live and Artificial Cells.
Bio-HhOST aims to create bio-hybrid materials with living and artificial cells for dynamic communication, enhancing tissue modeling and reducing animal use in drug research.
High-throughput ultrasound-based volumetric 3D printing for tissue engineering
SONOCRAFT aims to revolutionize myocardial cell construct bioprinting by combining rapid volumetric printing with ultrasonic manipulation to create functional cardiac models for drug testing and disease research.
Dypha: adding the dimension of time to cell culture
The δypha System aims to enhance drug development by providing a plug-and-play microfluidic adaptor for 96 well plates, enabling precise control of fluid kinetics in cell culture models.