SubsidieMeestersGlyco-protein arrays for functional virus surveillance
This project aims to assess the feasibility of glycan-protein arrays for early detection of pandemic influenza and coronavirus threats, enhancing public health surveillance.
Projectdetails
Introduction
This ERC PoC project aims to establish the technical and commercial feasibility of our recently developed glycan-arrays in which we determined the minimal receptor for duck, chicken, and human influenza A viruses, respectively.
Research Focus
We also determined structures vital for viruses as intermediate receptors on the avian-mammalian interface. With our experience in printing arrays, we also want to add proteinaceous receptors for coronaviruses.
Project Objectives
This mixed “glyco-protein” array will then be employed for functional surveillance of two virus families with significant pandemic threat.
Societal Impact
The ERC program “sugar-enable” has developed different glycan arrays that should be used in the real world to detect potential pandemic viruses as soon as possible, now making a substantial societal impact.
Feasibility Study
In this project, we aim to conduct a technical and commercial feasibility study.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-8-2024 |
| Einddatum | 31-1-2026 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSITEIT UTRECHTpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Glycoengineered erythrocytes for better influenza vaccinesThis project aims to validate glycan-engineered red blood cells for antigenic characterization of evolving influenza A/H3N2 viruses, enhancing seasonal vaccine development globally. | ERC Proof of... | € 150.000 | 2022 | Details |
Isotopically labelling of cell surface glycans to illuminate infectious processes at atomic resolutionGlyco13Cell aims to chemically remodel cell surface glycans using NMR probes to enhance understanding of glycan-lectin interactions for developing novel tools in infectious disease treatment. | ERC Starting... | € 1.500.000 | 2023 | Details |
Novel ApameR-Based Rapid Test Technology for Virus DetectionDeveloping a cost-effective RNA aptamer-based sensor for rapid point-of-care testing of avian influenza, meeting WHO ASSURED criteria, to enhance pathogen detection and containment. | ERC Proof of... | € 150.000 | 2023 | Details |
Universal building blocks for antigen presentation to uncover the flavivirus-directed antibody responseThe FLAVIR project aims to develop a structural proteomics toolkit using mass spectrometry and electron microscopy to enhance understanding of neutralizing antibody responses against flaviviruses for vaccine development. | ERC Starting... | € 1.687.500 | 2023 | Details |
GlycoRoads: A platform for the de novo design of glycansGlycoRoads aims to develop an AI-driven platform for de novo glycan design using molecular dynamics simulations to create a comprehensive database, enhancing customization for therapeutic and material applications. | ERC Proof of... | € 150.000 | 2025 | Details |
Glycoengineered erythrocytes for better influenza vaccines
This project aims to validate glycan-engineered red blood cells for antigenic characterization of evolving influenza A/H3N2 viruses, enhancing seasonal vaccine development globally.
Isotopically labelling of cell surface glycans to illuminate infectious processes at atomic resolution
Glyco13Cell aims to chemically remodel cell surface glycans using NMR probes to enhance understanding of glycan-lectin interactions for developing novel tools in infectious disease treatment.
Novel ApameR-Based Rapid Test Technology for Virus Detection
Developing a cost-effective RNA aptamer-based sensor for rapid point-of-care testing of avian influenza, meeting WHO ASSURED criteria, to enhance pathogen detection and containment.
Universal building blocks for antigen presentation to uncover the flavivirus-directed antibody response
The FLAVIR project aims to develop a structural proteomics toolkit using mass spectrometry and electron microscopy to enhance understanding of neutralizing antibody responses against flaviviruses for vaccine development.
GlycoRoads: A platform for the de novo design of glycans
GlycoRoads aims to develop an AI-driven platform for de novo glycan design using molecular dynamics simulations to create a comprehensive database, enhancing customization for therapeutic and material applications.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Micro array patches voor effectieve bestrijding infectieziektenDit project onderzoekt de haalbaarheid van vaccintoepassingen voor micro array technologie en ontwikkelt een roadmap voor veelbelovende vaccins tegen infectieziekten. | Mkb-innovati... | € 20.000 | 2020 | Details |
Inhibitor-Mediated Programming of GlycoformsThe project aims to revolutionize glycan manipulation using Inhibitor-Mediated Programming of Glycoforms (IMProGlyco) to create precision-engineered therapeutic proteins and enhance cellular functions. | EIC Pathfinder | € 2.998.878 | 2025 | Details |
FLow detection of virUses by graphene Field Effect Transistor microarraysFLUFET aims to develop an automated sensor using graphene technology for continuous detection of zoonotic viruses, enhancing pandemic prevention through real-time monitoring of animal farms. | EIC Pathfinder | € 3.200.092 | 2024 | Details |
Universal GPCR Activity Sensor for Next Generation Drug DiscoveryThis project aims to develop a novel single-assay technology platform for GPCR drug discovery, enhancing detection and classification of drug candidates to improve efficacy and reduce failures. | EIC Pathfinder | € 2.965.384 | 2023 | Details |
Precision control of glycosylation to open a new era of therapeutic antibodiesGlycoBoost aims to revolutionize monoclonal antibody design by producing therapeutics with uniform N-glycans, enhancing safety and efficacy for autoimmune disease treatments. | EIC Transition | € 2.499.540 | 2025 | Details |
Micro array patches voor effectieve bestrijding infectieziekten
Dit project onderzoekt de haalbaarheid van vaccintoepassingen voor micro array technologie en ontwikkelt een roadmap voor veelbelovende vaccins tegen infectieziekten.
Inhibitor-Mediated Programming of Glycoforms
The project aims to revolutionize glycan manipulation using Inhibitor-Mediated Programming of Glycoforms (IMProGlyco) to create precision-engineered therapeutic proteins and enhance cellular functions.
FLow detection of virUses by graphene Field Effect Transistor microarrays
FLUFET aims to develop an automated sensor using graphene technology for continuous detection of zoonotic viruses, enhancing pandemic prevention through real-time monitoring of animal farms.
Universal GPCR Activity Sensor for Next Generation Drug Discovery
This project aims to develop a novel single-assay technology platform for GPCR drug discovery, enhancing detection and classification of drug candidates to improve efficacy and reduce failures.
Precision control of glycosylation to open a new era of therapeutic antibodies
GlycoBoost aims to revolutionize monoclonal antibody design by producing therapeutics with uniform N-glycans, enhancing safety and efficacy for autoimmune disease treatments.