Molecular Control and Characterization of Chiral Hydrogen-bond Networks
HydroChiral aims to develop innovative spectroscopy techniques to investigate chiral water's role in biological processes, enhancing understanding of homochirality and advancing applications in chemistry and pharmaceuticals.
Projectdetails
Introduction
Chirality and water both play key roles in various aspects of biological functions. Disentangling water’s role in chiral recognition in biological processes is paramount to ultimately understanding the origins of homochirality.
Project Overview
HydroChiral proposes to do this by developing ground-breaking instrumentation that uses:
- Broadband molecular rotational spectroscopy
- Supersonic expansions
- Buffer gas cell technology
- Novel chiral capabilities
These technologies will explore pressing topics at the forefront of water research and chirality, such as:
- The generation and characterization of chiral water
- The generation of larger water clusters to examine the first solvation shell
- Absolute configuration determination for analytical applications
Methodology
This technique will differentiate between enantiomers, diastereomers, and conformers within complex gas mixtures. It will enable the study, at an unprecedented accuracy, of the chiral water structures that form in the solvation of biomolecules. This will help unravel the active role of water in most biological processes.
Innovation
The project will demonstrate the use of chiral techniques that have been developed for rotational spectroscopy on molecular clusters for the first time. It will utilize enantiomer-selective population transfer techniques to tilt the racemic nature of chiral water clusters and create enantiomerically enriched water.
Research Fields
The proposed research encompasses my three fields of expertise to perform cutting-edge research in:
- Water cluster science
- Chirality
- Solvation
This will leverage the advantageous features of rotational spectroscopy.
Expected Outcomes
The outcomes of HydroChiral will open new horizons for not only fundamental research in physical chemistry and molecular physics but also in applied fields ranging from analytical chemistry to asymmetric synthesis in pharmaceutical applications, such as drug discovery, where absolute configuration determination is crucial.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 2.000.000 |
Totale projectbegroting | € 2.000.000 |
Tijdlijn
Startdatum | 1-7-2024 |
Einddatum | 30-6-2029 |
Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSIDAD DE VALLADOLIDpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
Controlling chirality in atomically thin quantum electronic materialsCHIROTRONICS aims to experimentally observe and control chiral responses in atomically thin quantum materials to develop innovative chiral technologies for diverse applications. | ERC Starting... | € 1.799.250 | 2022 | Details |
Ultrafast molecular chirality: twisting light to twist electrons on ultrafast time scaleThe ULISSES project aims to develop efficient all-optical methods to study and control chiral molecular interactions and electron dynamics using tailored laser polarization techniques. | ERC Advanced... | € 2.476.743 | 2022 | Details |
Coherent Control of Chiral MoleculesThe project aims to generate an enantiomer-pure beam of chiral molecules from a racemic sample using advanced quantum state preparation and detection techniques. | ERC Starting... | € 1.809.735 | 2024 | Details |
Advanced Molecular ENantiodiscriminationThe AMEN project aims to develop scalable chiral microreactor technology for the selective production of pharmaceutical enantiomers, ensuring safety and efficacy in drug formulations. | ERC Proof of... | € 150.000 | 2024 | Details |
Precision measurement of parity violation with quantum-controlled and trapped chiral molecular ionsQ-ChiMP aims to investigate the role of the weak force in chemistry by measuring parity violation in chiral molecular ions using advanced vibrational spectroscopy for enhanced precision. | ERC Starting... | € 1.874.500 | 2023 | Details |
Controlling chirality in atomically thin quantum electronic materials
CHIROTRONICS aims to experimentally observe and control chiral responses in atomically thin quantum materials to develop innovative chiral technologies for diverse applications.
Ultrafast molecular chirality: twisting light to twist electrons on ultrafast time scale
The ULISSES project aims to develop efficient all-optical methods to study and control chiral molecular interactions and electron dynamics using tailored laser polarization techniques.
Coherent Control of Chiral Molecules
The project aims to generate an enantiomer-pure beam of chiral molecules from a racemic sample using advanced quantum state preparation and detection techniques.
Advanced Molecular ENantiodiscrimination
The AMEN project aims to develop scalable chiral microreactor technology for the selective production of pharmaceutical enantiomers, ensuring safety and efficacy in drug formulations.
Precision measurement of parity violation with quantum-controlled and trapped chiral molecular ions
Q-ChiMP aims to investigate the role of the weak force in chemistry by measuring parity violation in chiral molecular ions using advanced vibrational spectroscopy for enhanced precision.
Vergelijkbare projecten uit andere regelingen
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
Chiral separation of molecules enabled by enantioselective optical forces in integrated nanophotonic circuitsCHIRALFORCE aims to revolutionize enantiomer separation for drug discovery using silicon-based integrated waveguides and chiral optical forces for rapid, cost-effective processing. | EIC Pathfinder | € 3.263.726 | 2022 | Details |
Twisted nanophotonic technology for integrated chiroptical sensing of drugs on a chipTwistedNano aims to revolutionize drug discovery by developing integrated nanophotonic devices for ultrasensitive chiroptical spectroscopy on microfluidic chips, enhancing chiral sensing and diagnostics. | EIC Pathfinder | € 3.679.925 | 2022 | Details |
Holografisch vrij chloor & ethyleen metenHet project onderzoekt de haalbaarheid van holografische sensortechniek voor betrouwbare meting van vrij chloor in water en ethyleen bij rotting, met als doel kosten te verlagen en kwaliteitsbewaking te verbeteren. | Mkb-innovati... | € 19.400 | 2021 | Details |
Chiral separation of molecules enabled by enantioselective optical forces in integrated nanophotonic circuits
CHIRALFORCE aims to revolutionize enantiomer separation for drug discovery using silicon-based integrated waveguides and chiral optical forces for rapid, cost-effective processing.
Twisted nanophotonic technology for integrated chiroptical sensing of drugs on a chip
TwistedNano aims to revolutionize drug discovery by developing integrated nanophotonic devices for ultrasensitive chiroptical spectroscopy on microfluidic chips, enhancing chiral sensing and diagnostics.
Holografisch vrij chloor & ethyleen meten
Het project onderzoekt de haalbaarheid van holografische sensortechniek voor betrouwbare meting van vrij chloor in water en ethyleen bij rotting, met als doel kosten te verlagen en kwaliteitsbewaking te verbeteren.