Modelling Inter-Scale Energetics in GastroIntestinal ElectroMechanics

MiGEM aims to develop a comprehensive multiphysics model of gastrointestinal motility to advance research and therapies for GI disorders through innovative thermodynamic and experimental approaches.

Subsidie
€ 2.000.000
2025

Projectdetails

Introduction

The MiGEM proposal targets one of the remaining grand challenges in biomechanics: the development of a comprehensive, inter-scale, thermodynamically and energetically coherent multiphysics model of gastrointestinal (GI) motility.

Importance of the Challenge

Despite the importance of gastrointestinal disorders as a primary global health problem, electromechanical modelling of gastrointestinal motility still presents significant theoretical and experimental limitations compared to more advanced fields such as cardiovascular bioengineering.

Technical Difficulties

Technical difficulties exist due to the intrinsic multiscale nature of gastrointestinal tissues, the coupling of multiple cell types and roles, and the combination of electrical and mechanical phenomena involving different energetic mechanisms.

Potential Impact

MiGEM has the potential to unlock new frontiers in GI research, addressing several state-of-the-art problems in gastrointestinal motility and opening unprecedented opportunities in novel subject-specific therapies.

Scientific Approach

By adopting a rigorous theoretical-experimental scientific approach, MiGEM will advance state-of-the-art gastrointestinal theoretical modelling and experimental measurements, unveiling fundamental energetic mechanisms that govern stomach and intestine motility in health and disease.

Innovative Measurements

MiGEM will enable the first calorimetric measurement of tissue samples from the GI tract and create a new path in biomechanical modelling by assimilating innovative data into multiscale thermodynamic models.

Collaborative Network

The project will create a new network of scientists with complementary experimental and modelling skills, fostering cross-fertilization, providing senior-to-junior methodological transfer, and supporting gender balance.

Key Elements for Success

The scientific experience of the PI, the formal membership to the project of the ABI, University of Auckland, and the multiple scientific collaborations that the PI has engaged in for many years will be the key elements to successfully carry out an ambitious and high-risk project.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 2.000.000
Totale projectbegroting€ 2.000.000

Tijdlijn

Startdatum1-3-2025
Einddatum28-2-2030
Subsidiejaar2025

Partners & Locaties

Projectpartners

  • UNIVERSITA CAMPUS BIO MEDICO DI ROMApenvoerder
  • THE UNIVERSITY OF AUCKLAND

Land(en)

ItalyNew Zealand

Vergelijkbare projecten binnen European Research Council

ERC Starting...

Wireless magnetothermal entero-modulation

This project aims to develop a biocompatible magnetic gel for remote activation of intestinal tissue to modulate calcium signaling and neuropeptide release, addressing GI disorders non-invasively.

€ 1.500.000
ERC Starting...

Resolving metabolic interactions between the gut microbiota and the host with multi-omics-based modelling

This project aims to systematically characterize gut bacteria interactions and their metabolic contributions to host health using experimental and computational methods, enabling targeted microbiota interventions.

€ 1.499.323
ERC Starting...

Personalised Mechanobiological Models to Predict Tumour Growth and Anti-Cancer Drug Penetration

This project aims to develop a personalized cancer treatment framework by modeling stress-dependent tumor growth and drug penetration to enhance patient-specific therapy outcomes.

€ 1.499.693
ERC Advanced...

Engineering soft microdevices for the mechanical characterization and stimulation of microtissues

This project aims to advance mechanobiology by developing soft robotic micro-devices to study and manipulate 3D tissue responses, enhancing understanding of cell behavior and potential cancer treatments.

€ 3.475.660
ERC Consolid...

Impact Of The Gut Microbiota On Host Cells Energy Metabolism: Role In Health And In Inflammatory bowel disease

The ENERGISED project aims to explore how altered gut microbiota affects host cell energy metabolism in inflammatory bowel diseases to develop new microbiota-based therapies.

€ 1.999.265

Vergelijkbare projecten uit andere regelingen

EIC Pathfinder

Supervised morphogenesis in gastruloids

This project aims to develop advanced gastruloid technology to create larger, vascularized organ models that better mimic human physiology, reducing reliance on animal experiments.

€ 3.337.725