SubsidieMeestersHolographic Optical Tweezing Bioprinting (HOTB): Towards precise manipulation of cells for artificial multi-scaled vascularized tissues/organ printing.
The HOT-BIOPRINTING project aims to revolutionize tissue engineering by developing a holographic optical tweezing bioprinter for high-resolution, automated 3D bioprinting of complex, vascularized tissues.
Projectdetails
Introduction
Because current limitations in 3D bioprinting for tissue engineering stem from the fact that the multi-scaled vasculature associated with human microtissues and organs cannot be replicated. The overarching aim of the HOT-BIOPRINTING project is to deliver a methodology enabling the manufacturing of a new generation of tissue-like structures with properties mimicking more closely the complexity of biological tissues and organs.
Innovation
The innovation of HOT-BIOPRINTING lies in the development of a disruptive technology named Holographic Optical Tweezing Bioprinting (HOTB) for single and automatized multiple cell 3D bioprinting. The non-contact nature of light will eliminate the failures in bioprinting associated with instrumentation.
Along with the HOTB capabilities for manipulating single cells for printing, this will drive a new paradigm shift: resolution will be dictated by the cell size instead of by the mechanical component of the instrumentation. This new technological advancement for resolution enhancement while maintaining bioprinting speed using holographic automatization can open new opportunities to the tissue engineering and regenerative medicine community.
General Objectives
I propose the following general objectives that go beyond the state of the art in bioprinting human mimetic tissue:
- Generate the knowledge and develop a Holographic Optical Tweezer Bioprinter (HOTB) for high-definition single/multiple cell bioprinting.
- Demonstration and automatization for 3D multicellular printing for large area tissue generation.
- Overcome the challenges associated with existing biofabrication techniques (limited multi-scaled vascularization and oversimplified structures).
- Demonstrate lymph-node bioprinting with integrated vasculature.
Conclusion
This represents a big challenge; if achieved, it will revolutionize bioprint technology by increasing tissue complexity and responding to the demand for biofabricating multi-scale vascularized complex tissues and organs.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.965.525 |
| Totale projectbegroting | € 1.965.525 |
Tijdlijn
| Startdatum | 1-2-2024 |
| Einddatum | 31-1-2029 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSIDADE DA CORUNApenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
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|---|---|---|---|---|
4D bioprinting shape-morphing tissues using phototunable supramolecular hydrogelsmorphoPRINT aims to develop a dynamic hydrogel platform for bioprinted tissues that enables programmable shape-morphing, facilitating the creation of functional organs through controlled volumetric growth. | ERC Starting... | € 1.499.906 | 2023 | Details |
Human based bioinks to engineer physiologically relevant tissuesHumanINK aims to validate human-based bioinks for 3D bioprinting, creating advanced cell culture environments to enhance drug development and reduce reliance on animal testing. | ERC Proof of... | € 150.000 | 2022 | Details |
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A novel support material for 3D bioprinting and post-printing tissue growth: Print and GrowThe "Print and Grow" project aims to enhance 3D bioprinting stability and viability of tissue constructs through a novel microgel support, optimizing for diverse tissue types and in vivo applications. | ERC Proof of... | € 150.000 | 2022 | Details |
3D-assembly of interactive microgels to grow in vitro vascularized, structured, and beating human cardiac tissues in high-throughputHEARTBEAT aims to create personalized, vascularized millimeter-scale heart tissues using innovative microgel assemblies to enhance stem cell interactions and mimic native environments. | ERC Consolid... | € 2.969.219 | 2022 | Details |
4D bioprinting shape-morphing tissues using phototunable supramolecular hydrogels
morphoPRINT aims to develop a dynamic hydrogel platform for bioprinted tissues that enables programmable shape-morphing, facilitating the creation of functional organs through controlled volumetric growth.
Human based bioinks to engineer physiologically relevant tissues
HumanINK aims to validate human-based bioinks for 3D bioprinting, creating advanced cell culture environments to enhance drug development and reduce reliance on animal testing.
Laser biofabrication of 3D multicellular tissue with perfusible vascular network
This project aims to revolutionize organ regeneration by developing a 3D vascular system using advanced bioprinting techniques to enable effective perfusion in tissue constructs.
A novel support material for 3D bioprinting and post-printing tissue growth: Print and Grow
The "Print and Grow" project aims to enhance 3D bioprinting stability and viability of tissue constructs through a novel microgel support, optimizing for diverse tissue types and in vivo applications.
3D-assembly of interactive microgels to grow in vitro vascularized, structured, and beating human cardiac tissues in high-throughput
HEARTBEAT aims to create personalized, vascularized millimeter-scale heart tissues using innovative microgel assemblies to enhance stem cell interactions and mimic native environments.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) Comprised of Live and Artificial Cells.Bio-HhOST aims to create bio-hybrid materials with living and artificial cells for dynamic communication, enhancing tissue modeling and reducing animal use in drug research. | EIC Pathfinder | € 1.225.468 | 2024 | Details |
Better Bioprinting by Light-sheet LithographyB-BRIGHTER aims to develop a novel high-speed bioprinting technology for creating complex engineered tissues, enhancing drug testing and therapeutic applications while fostering healthcare innovation. | EIC Transition | € 2.093.331 | 2022 | Details |
High-throughput ultrasound-based volumetric 3D printing for tissue engineeringSONOCRAFT aims to revolutionize myocardial cell construct bioprinting by combining rapid volumetric printing with ultrasonic manipulation to create functional cardiac models for drug testing and disease research. | EIC Pathfinder | € 2.999.625 | 2025 | Details |
PRInted Symbiotic Materials as a dynamic platform for Living Tissues productionPRISM-LT aims to develop a flexible bioprinting platform using hybrid living materials to enhance stem cell differentiation with engineered helper cells for biomedical and food applications. | EIC Pathfinder | € 2.805.403 | 2022 | Details |
building vascular networks and Blood-Brain-Barriers through a Biomimetic manufacturing Technology for the fabrication of Human tissues and ORgansTHOR aims to revolutionize tissue engineering by creating patient-specific, fully functional human tissues using bioinspired mini-robots, eliminating the need for organ transplants. | EIC Pathfinder | € 3.994.150 | 2023 | Details |
Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) Comprised of Live and Artificial Cells.
Bio-HhOST aims to create bio-hybrid materials with living and artificial cells for dynamic communication, enhancing tissue modeling and reducing animal use in drug research.
Better Bioprinting by Light-sheet Lithography
B-BRIGHTER aims to develop a novel high-speed bioprinting technology for creating complex engineered tissues, enhancing drug testing and therapeutic applications while fostering healthcare innovation.
High-throughput ultrasound-based volumetric 3D printing for tissue engineering
SONOCRAFT aims to revolutionize myocardial cell construct bioprinting by combining rapid volumetric printing with ultrasonic manipulation to create functional cardiac models for drug testing and disease research.
PRInted Symbiotic Materials as a dynamic platform for Living Tissues production
PRISM-LT aims to develop a flexible bioprinting platform using hybrid living materials to enhance stem cell differentiation with engineered helper cells for biomedical and food applications.
building vascular networks and Blood-Brain-Barriers through a Biomimetic manufacturing Technology for the fabrication of Human tissues and ORgans
THOR aims to revolutionize tissue engineering by creating patient-specific, fully functional human tissues using bioinspired mini-robots, eliminating the need for organ transplants.