Cold Organic Chemistry

This project explores organic reactions under cold, low-energy, and high-radiation conditions to uncover mechanisms like quantum-mechanical tunneling that may explain the formation of complex organic molecules in space.

Subsidie
€ 2.493.529
2022

Projectdetails

Introduction

This proposal ventures into organic chemical reactions under not-so-common conditions, namely in the cold, at insufficient energies, and under the action of hard radiation. As many organic molecules have been discovered in space or brought to earth in meteorites, they must have formed under such conditions through hitherto largely undisclosed mechanisms.

Key Hypotheses

One key hypothesis is that quantum-mechanical tunneling (QMT) and novel reactions with exceptionally low barriers are at work. Hence, one of the key objectives is to uncover how QMT, where reactions occur through and not over barriers, controls chemical reactivity and selectivity.

Research Goals

A second goal is the examination of cryogenic reactions of hydroxycarbenes or enols with carbonyl compounds. Our methods include:

  1. Organic synthesis of starting materials (also isotopically labelled) and products.
  2. Infrared as well as ultraviolet/visible matrix-isolation spectroscopy.
  3. Ab initio computations of structures, spectra, and potential energy surfaces.
  4. QMT rate calculations.

Isotope-Selective Reactions

We will examine isotope-selective reactions of competing QMT reactions that can be made selective through strategic isotope incorporation. QMT also offers new ways to activate carbon dioxide and even to catalyze reactions.

Proposed Synthesis

We propose a unifying synthesis of carbohydrates and alpha-amino acids through a common mechanistic scenario, namely a newly discovered hetero-carbonyl-ene reaction of carbenes or enols in the gas phase.

Exploration of Non-Equilibrium Chemistry

Finally, chemistry far from thermodynamic equilibrium is explored by probing the activation and reaction of highly stable molecules under irradiation with energetic electrons, thereby mimicking conditions of the interstellar medium exposed to galactic cosmic rays. This should shed light on the formation of larger “complex organic molecules” found in this medium and often considered as building blocks for life.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 2.493.529
Totale projectbegroting€ 2.493.529

Tijdlijn

Startdatum1-9-2022
Einddatum31-8-2027
Subsidiejaar2022

Partners & Locaties

Projectpartners

  • JUSTUS-LIEBIG-UNIVERSITAET GIESSENpenvoerder

Land(en)

Germany

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