Assumption-Lean (Causal) Modelling and Estimation: A Paradigm Shift from Traditional Statistical Modelling

Develop a flexible 'assumption-lean modelling' framework for causal inference that minimizes bias and enhances interpretability in statistical analyses using debiased learning techniques.

Subsidie
€ 2.445.063
2024

Projectdetails

I propose a cutting-edge and transformative paradigm for statistical modelling that is crucial to enhance the quality of data analyses.

Introduction

Leveraging my expertise in causal inference and semiparametric statistics, I will establish the fundamental principles of a comprehensive estimation theory. This theory maps model parameters onto generic, interpretable, model-free estimands (e.g., association or effect measures) with favourable efficiency bounds. Additionally, it harnesses the power of debiased (statistical/machine) learning techniques to estimate these.

Core Objective

My core objective is to develop a flexible and accessible data modelling framework, called ‘assumption-lean modelling’. This framework will deliver minimal bias and maximal interpretability, even in the presence of model misspecification. It will also provide honest confidence bounds that account for model uncertainty.

Debiased Learning

Debiased learning is at the core of this research. While gaining popularity, a rigorous scientific optimality theory is lacking. I shall draw on my expertise in (bias-reduced) double robust estimation to develop optimal debiased learning estimators. These estimators will utilize learners that optimize strategically chosen loss functions to achieve:

  1. Low variance
  2. High stability

Additionally, they will provide confidence intervals that are valid under weak conditions on the learners.

Timely Developments

I will connect to timely, exciting developments in statistics, such as debiased learning of function-valued parameters and the construction of confidence bounds for such parameters. I will offer novel avenues into these problems by incorporating the assumption-lean modelling principles and connecting to real-world needs.

Application Areas

I will develop assumption-lean modelling strategies to tackle significant challenges in causal modelling, including:

  1. Target trial emulation
  2. Causal mediation analysis
  3. Statistical modelling of dependent outcomes

I will deliver methods with potential impact on all empirical sciences, as well as on the foundations of the discipline of statistical modelling.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 2.445.063
Totale projectbegroting€ 2.445.063

Tijdlijn

Startdatum1-10-2024
Einddatum30-9-2029
Subsidiejaar2024

Partners & Locaties

Projectpartners

  • UNIVERSITEIT GENTpenvoerder

Land(en)

Belgium

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