Novel microsensing platform for remote patient monitoring

Introduction

We have developed and in-human validated a new generation of implantable microstimulators for neuroprosthetics, accomplishing very thin (< 1 mm) and flexible devices with an unprecedented level of miniaturization as they lack batteries and bulky components.

Technology Overview

Our microstimulators are powered by an external system using an innovative wireless power transfer method that uses the human body as an electrical conductor of innocuous high-frequency currents.

Application in Remote Patient Monitoring

While developing the microstimulators, we realized that this technology could also be used to create minimally invasive implants capable of sensing relevant biomedical parameters for remote patient monitoring (RPM). Our technology has the potential to revolutionize RPM, as it allows us to:

• Combine different sensing capabilities in a single device
• Create a network of implants for multi-site sensing

Focus on Chronic Heart Failure

After analyzing several opportunities, we decided to focus the applicability of our sensing platform to chronic heart failure (HF) monitoring. Chronic HF is a long-term, persistent condition in which the heart is not able to efficiently pump blood to the body, causing symptoms such as limited physical activity and swelling.

With time, the patient decompensates, leading to repeated costly hospitalizations with an annual cost of care of US$30,000 per patient in the US, and a 5-year mortality rate of 50%.

Emerging Clinical Reality

RPM using implanted sensors is an emerging clinical reality for HF patients, as it optimizes medical management and treatment, improving their quality of life and outcomes.

Project Objective

The objective of FORESEE is to bring the implantable microsensing platform for RPM of HF patients from TRL3 up to completion of TRL5, and to develop a successful business strategy to ensure its future market access, benefiting almost 10.5 million HF patients in the EU and US that are candidates for RPM.

Conclusion

The technological and business activities developed by our team, with strong scientific and business expertise, will ensure tech-to-market transition.