New generation of bioactive coating for intravenous catheters and implantable medical devices to prevent infections and thrombosis

Introduction

Catheters and implantable medical devices contacting with the bloodstream are sources of internal blood infections and thrombosis. Catheter-related bloodstream infections are one of the major causes of patient morbidity and mortality in intensive care units.

Impact on Healthcare

Both thrombosis and catheter-related infections lead to prolonged hospital stays, increased risks of mortality, and high costs for the healthcare system. Currently, there is no coating technology on the market that allows for the prevention of these two complications at once.

Innovative Coating Technology

We developed a new innovative coating technology that enables simultaneous prevention of thrombosis and internal bloodstream infections. This coating is made of layer-by-layer cross-linked nanogels that can be loaded with an antithrombotic and/or antibiotic drug.

Mechanism of Action

We found that the layer-by-layer assembly of these nanogels controls the amount of releasable bioactive agents from coated surfaces. The innovation of our technology is linked to the wider space of used nanoreservoirs that can entrap several bioactive molecules, thus combining several biological activities in a single coating.

Versatility of Application

In addition, these nanoreservoirs can be deposited as a coating on the surface of any biomaterial or medical device, whether metallic, biological, or polymeric.

Consortium and Collaboration

We have built a consortium that combines the key technical and business experience to bring our innovative coating product to market readiness.

Key Partners

• CMD-Coat: A young SME that counts with top researchers and specialists in the field of cardiovascular diseases, biologists, chemists, and pharmacists.
• Fresci: A company specializing in business strategy and innovation management.

Together, we aim to accelerate the technological development and validation of our Coati-X technology and bring to the market a new bioactive coating solution for implantable medical devices.