Transforming brain surgery by advancing functional-guided neuronavigational imaging

HyperProbe is an innovative all-optical imaging system using hyperspectral imaging and AI to enhance intraoperative neuronavigation and biomarker analysis during brain tumor surgeries.

Subsidie
€ 3.360.825
2022

Projectdetails

Introduction

In recent years, through the advancement of imaging technologies (such as MRI, PET, CT, among others), clinical localisation of lesions of the central nervous system (CNS) pre-surgery has made it possible for neurosurgeons to plan and navigate away from functional brain locations when removing tumours.

Challenges in Neuronavigation

However, neuronavigation in the surgical management of brain tumours remains a significant challenge due to the inability to maintain accurate spatial information of lesioned and non-lesioned locations intraoperatively.

Project Overview

To answer this challenge, we have put together a team of engineers, physicists, data scientists, and neurosurgeons to develop an innovative, all-optical intraoperative imaging system based on:

  1. Hyperspectral imaging (HSI) for rapid, multi-wavelength spectral acquisition.
  2. Artificial intelligence (AI) for image reconstruction and molecular fingerprint recognition.

HyperProbe Features

Our intraoperative HSI system (HyperProbe) will:

  1. Map, monitor, and quantify biomolecules of interest.
  2. Be handheld and user-friendly.
  3. Apply AI-based methods for:
    • The reconstruction of spectral images.
    • The analysis of spatio-spectral data.
    • The development and quantification of novel biomarkers.

Validation Process

We will validate the developed capacity in:

  • Phantoms.
  • In vivo against gold standard modalities in neuronavigational imaging.
  • Finally, provide proof-of-principle during brain tumour surgery.

Project Aim

HyperProbe aims at providing functional and structural information on biomarkers of interest that is currently missing during neuro-oncological interventions.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 3.360.825
Totale projectbegroting€ 3.548.325

Tijdlijn

Startdatum1-10-2022
Einddatum30-9-2027
Subsidiejaar2022

Partners & Locaties

Projectpartners

  • UNIVERSITA DEGLI STUDI DI FIRENZEpenvoerder
  • EMOLED SOCIETA A RESPONSABILITA LIMITATA
  • TECHNISCHE UNIVERSITAET MUENCHEN
  • UNIVERSITE LYON 1 CLAUDE BERNARD
  • AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
  • EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
  • HOSPICES CIVILS DE LYON
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
  • UNIVERSITY COLLEGE LONDON

Land(en)

ItalyGermanyFranceAustriaUnited Kingdom

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