Silk fibroin tissue grafting for peripheral nerve repair

Introduction

Peripheral nerve injury is a major source of disability, impairing muscle movement or normal sensations. Annually, 4 million people experience traumatic nerve damage.

Current Challenges

Current solutions do not always achieve full motor and sensory recovery, leading to:

• Loss of sensation/function
• Pain
• Significant impact on patients’ lives

With 50% of nerve repair procedures being unsuccessful, patients require prolonged rehabilitation. Furthermore, 30% of them experience permanent disability, producing a high socio-economic burden.

Innovative Solution

KLISBio has developed SILKBridge, a novel cost-effective nerve guide made of silk fibroin for safe and efficient peripheral nerve repair.

Clinical Testing

KLISBio’s solution has been clinically tested with a first in human (FIH) study.

Benefits of SILKBridge

SILKBridge supports and protects the regenerating nerve from compressive forces, restoring its function and reducing pain without patient discomfort.

Enhanced Healing

SILKBridge enhances nerve healing without immune rejection or fibrosis, which helps in:

1. Reducing the costs of rehabilitation
2. Minimizing prolonged surgeries