HB-086 and HB-097 for Treatment of Chronic Sensory Neuronal Disorders - Neuropathic Pain and Hearing Loss
HB-086 and HB-097 are therapeutic proteins targeting sensory nerve cells to treat chronic pain and hearing loss, demonstrating significant pain relief and hearing preservation in preclinical models.
Projectdetails
Introduction
HB-086 and HB-097 comprise our portfolio of therapeutic proteins. They are a family of growth factors with actions on sensory nerve cells and represent novel treatment approaches and a paradigm shift for medical treatment and prevention of severe, chronic conditions such as pain and hearing loss.
Mechanism of Action
The drug candidates target sensory nerve cells and their support cells in dorsal root ganglia and the inner ear. Evidence indicates a mode of action including:
- Normalisation of impaired neuronal-glial crosstalk
- Protection and regeneration of sensory nerve fibres
These mechanisms underpin increased peripheral afferent drive associated with chronic pain and apoptotic hearing loss.
Preclinical Data
Preclinical data confirm that:
- HB-086 completely abolishes pain sensation across different models.
- HB-097 preserves the sense of hearing in relevant models.
Dosing and Disease Progression
Importantly, documented prolonged effects warrant biweekly or monthly dosing and prevention of further disease progression.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 2.325.312 |
Totale projectbegroting | € 3.321.875 |
Tijdlijn
Startdatum | 1-6-2022 |
Einddatum | 31-5-2025 |
Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- HOBA THERAPEUTICS APSpenvoerder
Land(en)
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PAIN-CARE aims to develop Schwann cell selective analgesic drugs to effectively treat chronic pain with fewer side effects than current NSAIDs and opioids, advancing towards pre-commercialization.
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