A novel combination treatment effective against all multidrug-resistant pathogens deemed as a critical priority by the WHO

Introduction

Antimicrobial resistance (AMR) due to multidrug-resistant Gram-negative bacteria is an increasingly serious healthcare threat, exacerbated by major economic issues underlying the development of new antibacterial drugs.

Problem Statement

The effectiveness of β-lactam antibiotics, the most important class of antibacterial agents, is impaired by the production of β-lactamase enzymes by drug-resistant bacteria.

Project Overview

We are developing a combination of a well-known antibiotic (meropenem) and ANT3310, our proprietary, best-in-class serine-β-lactamase inhibitor, intended for the treatment of hospital-acquired infections caused by drug-resistant pathogens.

Efficacy

Our treatment has been pre-clinically proven to be efficacious against all three pathogens deemed a critical priority by the World Health Organization (WHO).

Clinical Trials and Future Plans

We will conduct three clinical trials and subsequently out-license ANT3310 to a pharmaceutical partner.

Market Expectations

We expect market approval by 2029 and that ANT3310 will generate over €10bn in sales within 13 years.